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. 1983 Feb;39(2):800–806. doi: 10.1128/iai.39.2.800-806.1983

Enhancement of Antigen-Specific Suppression by Muramyl Dipeptide

Thomas A Ferguson 1, Nancy J Krieger 1, Amadeo Pesce 1, J Gabriel Michael 1
PMCID: PMC348020  PMID: 6187686

Abstract

The effect of the synthetic adjuvant MDP (N-acetyl-muramyl-L-alanyl-D-isoglu-tamine) on the generation of antigen-specific suppression was investigated. Suppression of the anti-bovine serum albumin response, which was achieved by intravenous administration of a peptic fragment of the antigen, was greatly enhanced by simultaneous administration of MDP. Induction of suppression by a combination of bovine serum albumin fragments and MDP was found to be antigen specific and appeared to occur via the generation of antigen-specific suppressor T cells.

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Selected References

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