Table V.

Focal areas with decreased Vesicular Acetylcholine Transporter Binding Site Index (VATSBI) voxel-cerebellar ratios in four participants with Rett syndrome (RTT) who received single photon emission computed tomography (SPECT) of the brain for sixty (60) minutes, twenty-four (24) hours following the intravenous injection of approximately 333 MBq (9 mCi) (−)-5-[¹²³I]iodobenzovesamicol ([¹²³I]IBVM) (Figure 5)

XYZ coordinates of peak % change			% change	Volume (mL)	Description (Brodman area numbers)
Left hemisphere:
−14	−78	34	42.4	7.1	Parieto-occipital junction (17,18,31)
−4	−34	−4	39.2	3.9	Superior colliculus
−38	−28	12	38.9	8.9	Insula-transverse temporal gyrus
−4	−40	66	34.7	1.2	Post-central gyrus (21)
Right hemisphere:
12	−22	46	35.6	2.0	Cingulate gyrus (31)
52	12	−12	34.2	2.6	Superior temporal gyrus (38)