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. 1983 Feb;39(2):844–850. doi: 10.1128/iai.39.2.844-850.1983

Hemadsorption and virulence are separable properties of Mycoplasma pneumoniae.

D K Leith, E J Hansen, R M Wilson, D C Krause, J B Baseman
PMCID: PMC348026  PMID: 6403462

Abstract

A selective enrichment technique was used to isolate a hemadsorption-positive revertant of a hemadsorption-negative mutant strain of Mycoplasma pneumoniae. This hemadsorption-positive revertant was shown to have simultaneously regained both the ability to attach to neuraminidase-sensitive receptors on the tracheal ring respiratory epithelium in vitro and the ability to synthesize three virulent-strain-specific proteins which were not synthesized by the hemadsorption-negative mutant. Despite the persistence of the revertant in hamster lung tissue for 9 to 12 weeks postinfection, no cytopathology was observed. Intranasal inoculation of the revertant provided limited protection against a challenge dose of virulent M. pneumoniae.

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Selected References

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