Abstract
The bactericidal capacity of neutrophils from healthy adults, male children with chronic granulomatous disease, and obligate heterozygote mothers for type Ic group B streptococci was assessed, using a fluorochrome microassay. Neutrophils from patients with chronic granulomatous disease had impaired bactericidal capacity for group B streptococci when compared with adults (P less than 0.01). Carriers demonstrated intermediate killing capacity.
Full text
PDF



Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Allen R. C., Mills E. L., McNitt T. R., Quie P. G. Role of myeloperoxidase and bacterial metabolism in chemiluminescence of granulocytes from patients with chronic granulomatous disease. J Infect Dis. 1981 Oct;144(4):344–348. doi: 10.1093/infdis/144.4.344. [DOI] [PubMed] [Google Scholar]
- BRIDGES R. A., BERENDES H., GOOD R. A. A fatal granulomatous disease of childhood; the clinical, pathological, and laboratory features of a new syndrome. AMA J Dis Child. 1959 Apr;97(4):387–408. [PubMed] [Google Scholar]
- Baehner R. L., Nathan D. G. Quantitative nitroblue tetrazolium test in chronic granulomatous disease. N Engl J Med. 1968 May 2;278(18):971–976. doi: 10.1056/NEJM196805022781801. [DOI] [PubMed] [Google Scholar]
- Becker I. D., Robinson O. M., Bazán T. S., López-Osuna M., Kretschmer R. R. Bactericidal capacity of newborn phagocytes against group B beta-hemolytic streptococci. Infect Immun. 1981 Nov;34(2):535–539. doi: 10.1128/iai.34.2.535-539.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Douglas S. D. Analytic review: disorders of phagocyte function. Blood. 1970 Jun;35(6):851–866. [PubMed] [Google Scholar]
- Douglas S. D., Davis W. C., Fudenberg H. H. Granulocytopathies: pleomorphism of neutrophil dysfunction. Am J Med. 1969 Jun;46(6):901–909. doi: 10.1016/0002-9343(69)90091-6. [DOI] [PubMed] [Google Scholar]
- Gmünder F. K., Seger R. A. Chronic granulomatous disease: mode of action of sulfamethoxazole/trimethoprim. Pediatr Res. 1981 Dec;15(12):1533–1537. doi: 10.1203/00006450-198112000-00017. [DOI] [PubMed] [Google Scholar]
- Johnston R. B., Jr, Baehner R. L. Chronic granulomatous disease: correlation between pathogenesis and clinical findings. Pediatrics. 1971 Nov;48(5):730–739. [PubMed] [Google Scholar]
- Johnston R. B., Jr, Wilfert C. M., Buckley R. H., Webb L. S., DcChatelet L. R., McCall C. E. Enhanced bactericidal activity of phagocytes from patients with chronic granulomatous disease in the presence of sulphisoxazole. Lancet. 1975 Apr 12;1(7911):824–827. doi: 10.1016/s0140-6736(75)93002-0. [DOI] [PubMed] [Google Scholar]
- Johnston R. B., Newman S. L. Chronic granulomatous disease. Pediatr Clin North Am. 1977 May;24(2):365–376. doi: 10.1016/s0031-3955(16)33424-1. [DOI] [PubMed] [Google Scholar]
- Kaplan E. L., Laxdal T., Quie P. G. Studies of polymorphonuclear leukocytes from patients with chronic granulomatous disease of childhood: bactericidal capacity for streptococci. Pediatrics. 1968 Mar;41(3):591–599. [PubMed] [Google Scholar]
- Kasten F. H. Cytochemical studies with acridine orange and the influence of dye contaminants in the staining of nucleic acids. Int Rev Cytol. 1967;21:141–202. doi: 10.1016/s0074-7696(08)60814-1. [DOI] [PubMed] [Google Scholar]
- Klebanoff S. J., White L. R. Iodination defect in the leukocytes of a patient with chronic granulomatous disease of childhood. N Engl J Med. 1969 Feb 27;280(9):460–466. doi: 10.1056/NEJM196902272800902. [DOI] [PubMed] [Google Scholar]
- Lazarus G. M., Neu H. C. Agents responsible for infection in chronic granulomatous disease of childhood. J Pediatr. 1975 Mar;86(3):415–417. doi: 10.1016/s0022-3476(75)80975-9. [DOI] [PubMed] [Google Scholar]
- Mandell G. L., Hook E. W. Leukocyte bactericidal activity in chronic granulomatous disease: correlation of bacterial hydrogen peroxide production and susceptibility to intracellular killing. J Bacteriol. 1969 Oct;100(1):531–532. doi: 10.1128/jb.100.1.531-532.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mandell G. L., Hook E. W. Leukocyte function in chronic granulomatous disease of childhood. Studies on a seventeen year old boy. Am J Med. 1969 Sep;47(3):473–486. doi: 10.1016/0002-9343(69)90231-9. [DOI] [PubMed] [Google Scholar]
- Pantazis C. G., Kniker W. T. Assessment of blood leukocyte microbial killing by using a new fluorochrome microassay. J Reticuloendothel Soc. 1979 Aug;26(2):155–170. [PubMed] [Google Scholar]
- Philippart A. I., Colodny A. H., Baehner R. L. Continuous antibiotic therapy in chronic granulomatous disease: preliminary communication. Pediatrics. 1972 Dec;50(6):923–925. [PubMed] [Google Scholar]
- Pincus S. H., Klebanoff S. J. Quantitative leukocyte iodination. N Engl J Med. 1971 Apr 8;284(14):744–750. doi: 10.1056/NEJM197104082841402. [DOI] [PubMed] [Google Scholar]
- Pitt J., Bernheimer H. P. Role of peroxide in phagocytic killing of pneumococci. Infect Immun. 1974 Jan;9(1):48–52. doi: 10.1128/iai.9.1.48-52.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Quie P. G. Pathology of bactericidal power of neutrophils. Semin Hematol. 1975 Apr;12(2):143–160. [PubMed] [Google Scholar]
- Segal A. W., Geisow M., Garcia R., Harper A., Miller R. The respiratory burst of phagocytic cells is associated with a rise in vacuolar pH. Nature. 1981 Apr 2;290(5805):406–409. doi: 10.1038/290406a0. [DOI] [PubMed] [Google Scholar]
- Segal A. W., Peters T. J. Characterisation of the enzyme defect in chronic granulomatous disease. Lancet. 1976 Jun 26;1(7974):1363–1365. doi: 10.1016/s0140-6736(76)93021-x. [DOI] [PubMed] [Google Scholar]
- Thompson E. N., Soothill J. F. Chronic granulomatous disease: quantitative clinicopathological relationships. Arch Dis Child. 1970 Feb;45(239):24–32. doi: 10.1136/adc.45.239.24. [DOI] [PMC free article] [PubMed] [Google Scholar]
