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. 1983 Feb;39(2):1004–1005. doi: 10.1128/iai.39.2.1004-1005.1983

Differential Susceptibility of Chlamydiae to Exogenous Fibroblast Interferon

Gerald I Byrne 1, Constance D Rothermel 2
PMCID: PMC348050  PMID: 6832807

Abstract

Mouse fibroblasts (L cells) were incubated for 5 h with 1,000 U of murine fibroblast interferon (MuIFN α+ β) per ml and then were infected with either Chlamydia trachomatis (LGV 440), C. psittaci (6BC), or C. psittaci (Cal 10). Intracellular development of C. trachomatis was reduced 90% in interferon-treated cells 24 h after infection when compared with controls, whereas C. psittaci growth was not affected in interferon-treated cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Byrne G. I., Moulder J. W. Parasite-specified phagocytosis of Chlamydia psittaci and Chlamydia trachomatis by L and HeLa cells. Infect Immun. 1978 Feb;19(2):598–606. doi: 10.1128/iai.19.2.598-606.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Caldwell H. D., Kuo C. C., Kenny G. E. Antigenic analysis of Chlamydiae by two-dimensional immunoelectrophoresis. II. A trachoma-LGV-specific antigen. J Immunol. 1975 Oct;115(4):969–975. [PubMed] [Google Scholar]
  3. Dhir S. P., Hakomori S., Kenny G. E., Grayston J. T. Immunochemical studies on chlamydial group antigen (presence of a 2-keto-3-deoxycarbohydrate as immunodominant group). J Immunol. 1972 Jul;109(1):116–122. [PubMed] [Google Scholar]
  4. Hanna L., Merigan T. C., Jawetz E. Inhibition of TRIC agents by virus-induced interferon. Proc Soc Exp Biol Med. 1966 Jun;122(2):417–421. doi: 10.3181/00379727-122-31150. [DOI] [PubMed] [Google Scholar]
  5. Hatch T. P. Competition between Chlamydia psittaci and L cells for host isoleucine pools: a limiting factor in chlamydial multiplication. Infect Immun. 1975 Jul;12(1):211–220. doi: 10.1128/iai.12.1.211-220.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Havell E. A., Vilcek J. Production of high-titered interferon in cultures of human diploid cells. Antimicrob Agents Chemother. 1972 Dec;2(6):476–484. doi: 10.1128/aac.2.6.476. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Jenkin H. M., Lu Y. K. Induction of interferon by the Bour strain of trachoma in HeLa 229 cells. Am J Ophthalmol. 1967 May;63(5 Suppl):1110–1115. doi: 10.1016/0002-9394(67)94091-3. [DOI] [PubMed] [Google Scholar]
  8. Kazar J., Gillmore J. D., Gordon F. B. Effect of Interferon and Interferon Inducers on Infections with a Nonviral Intracellular Microorganism, Chlamydia trachomatis. Infect Immun. 1971 Jun;3(6):825–832. doi: 10.1128/iai.3.6.825-832.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Kingsbury D. T., Weiss E. Lack of deoxyribonucleic acid homology between species of the genus Chlamydia. J Bacteriol. 1968 Oct;96(4):1421–1423. doi: 10.1128/jb.96.4.1421-1423.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Schachter J., Caldwell H. D. Chlamydiae. Annu Rev Microbiol. 1980;34:285–309. doi: 10.1146/annurev.mi.34.100180.001441. [DOI] [PubMed] [Google Scholar]

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