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. 1983 Mar;39(3):1481–1484. doi: 10.1128/iai.39.3.1481-1484.1983

Polyclonal activation of B-lymphocytes in vivo by Salmonella typhimurium lipoprotein.

R B Johnson, S Köhl, W G Bessler
PMCID: PMC348120  PMID: 6341238

Abstract

Lipoprotein prepared from the outer membrane of Salmonella typhimurium is a polyclonal activator of murine B-lymphocytes. It was shown to be mitogenic for splenic cultures, stimulating increased incorporation of [3H]thymidine into DNA. When injected intravenously into mice, the lipoprotein induced splenomegaly and polyclonal B-cell activation. The latter was evident from an increase in the number of plaque-forming cells against trinitrophenylated sheep erythrocytes. Similar results were obtained with Escherichia coli lipoprotein.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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