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. 1983 Jun;40(3):1218–1222. doi: 10.1128/iai.40.3.1218-1222.1983

Immunoglobulin and complement in tissues of mice infected with Nocardia brasiliensis.

C Conde, R Mancilla, M Fresan, L Ortiz-Ortiz
PMCID: PMC348180  PMID: 6852920

Abstract

Two weeks after mice had been infected in the footpad with cells of Nocardia brasiliensis, immunoglobulin and C3 deposits were observed in tissue from the inoculation site. Both immunoglobulin and C3 were found in the actinomycotic granules that characterize the mycetoma and in the surrounding inflammatory zones, in which plasma cells were also present. Although anti-N. brasiliensis specificity was evidenced at 14 days postinfection in an eluate of infected tissue by an immunoenzymatic assay, no such antibody was found in the serum until 45 days postinfection. Immune complexes in the lesions, as indicated by the presence of C3, may also contribute to the pathology of the disease.

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Selected References

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  1. Beaman B. L., Gershwin M. E., Maslan S. Infectious agents in immunodeficient murine models: pathogenicity of Nocardia asteroides in congenitally athymic (nude) and hereditarily asplenic (Dh/+) mice. Infect Immun. 1978 May;20(2):381–387. doi: 10.1128/iai.20.2.381-387.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Beaman B. L., Goldstein E., Gershwin M. E., Maslan S., Lippert W. Lung response to congenitally athymic (nude), heterozygous, and Swiss Webster mice to aerogenic and intranasal infection by Nocardia asteroides. Infect Immun. 1978 Dec;22(3):867–877. doi: 10.1128/iai.22.3.867-877.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Beaman B. L. Interaction of Nocardia asteroides at different phases of growth with in vitro-maintained macrophages obtained from the lungs of normal and immunized rabbits. Infect Immun. 1979 Oct;26(1):355–361. doi: 10.1128/iai.26.1.355-361.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Clinton B. A., Weigle W. E. Cellular events during the induction of experimental thyroiditis in the rabbit. J Exp Med. 1972 Dec 1;136(6):1605–1615. doi: 10.1084/jem.136.6.1605. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Filice G. A., Beaman B. L., Remington J. S. Effects of activated macrophages on Nacardia asteroides. Infect Immun. 1980 Feb;27(2):643–649. doi: 10.1128/iai.27.2.643-649.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Folb P. I., Timme A., Horowitz A. Nocardia infections in congenitally athymic (nude) mice and in other inbred mouse strains. Infect Immun. 1977 Nov;18(2):459–466. doi: 10.1128/iai.18.2.459-466.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Johnson R. B., Jr, Libby R. M., Nakamura R. M. Comparison of glucose oxidase and peroxidase as labels for antibody in enzyme-linked immunosorbent assay. J Immunoassay. 1980;1(1):27–37. doi: 10.1080/01971528008055774. [DOI] [PubMed] [Google Scholar]
  8. Krick J. A., Remington J. S. Resistance to infection with Nocardia asteroides. J Infect Dis. 1975 Jun;131(6):665–672. doi: 10.1093/infdis/131.6.665. [DOI] [PubMed] [Google Scholar]
  9. Lagrange P. H., Mackaness G. B., Miller T. E. Influence of dose and route of antigen injection on the immunological induction of T cells. J Exp Med. 1974 Mar 1;139(3):528–542. doi: 10.1084/jem.139.3.528. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. López J. S., Jensen F. J., Mendoza F., Ortíz-Ortíz L. Anticuerpos monoclonales contra Entamoeba histolytica. Arch Invest Med (Mex) 1982;13 (Suppl 3):291–295. [PubMed] [Google Scholar]
  11. McMurray D. N. Mechanisms of anergy in tuberculosis. Chest. 1980 Jan;77(1):4–5. doi: 10.1378/chest.77.1.4. [DOI] [PubMed] [Google Scholar]
  12. Melendro E. I., Contreras M. F., Ximénez C., García-Maynez A. M., Ortiz-Ortiz L. Changes in host resistance caused by Nocardia brasiliensis in mice: cross-protection against Listeria monocytogenes. Int Arch Allergy Appl Immunol. 1978;57(1):74–81. doi: 10.1159/000232086. [DOI] [PubMed] [Google Scholar]
  13. Ortiz-Oritz L., Parks D. E., Lopez J. S., Weigle W. O. B-lymphocyte activation with an extract of Nocardia brasiliensis. Infect Immun. 1979 Aug;25(2):627–634. doi: 10.1128/iai.25.2.627-634.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Ortiz-Ortiz L., Bojalil L. F., Contreras M. F. Delayed hypersensitivity to polysaccharides from nocardia. J Immunol. 1972 May;108(5):1409–1413. [PubMed] [Google Scholar]
  15. Ortiz-Ortiz L., Contreras M. F., Bujalil L. F. Cytoplasmic antigens from Nocardia elicting a specific delayed hypersensitivity. Infect Immun. 1972 Jun;5(6):879–882. doi: 10.1128/iai.5.6.879-882.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Ortiz-Ortiz L., Solarolo E. B., Bojalil L. F. Delayed hypersensitivity to ribosomal protein from BCG. J Immunol. 1971 Oct;107(4):1022–1026. [PubMed] [Google Scholar]
  17. Rico G., Ochoa R., Oliva A., Gonzalez-Mendoza A., Walker S. M., Ortiz-Ortiz L. Enhanced resistance to Nocardia brasiliensis infection in mice depleted of antigen-specific B cells. J Immunol. 1982 Oct;129(4):1688–1693. [PubMed] [Google Scholar]
  18. Woodroffe A. J., Wilson C. B. An evaluation of elution techniques in the study of immune complex glomerulonephritis. J Immunol. 1977 May;118(5):1788–1794. [PubMed] [Google Scholar]
  19. Ximénez C., Melendro E. I., González-Mendoza A., García A. M., Martínez A., Ortiz-Ortiz L. Resistance to Nocardia brasiliensis infection in mice immunized with either Nocardia or BCG. Mycopathologia. 1980 Mar 17;70(2):117–122. doi: 10.1007/BF00443077. [DOI] [PubMed] [Google Scholar]

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