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. 1980 Jan;77(1):257–261. doi: 10.1073/pnas.77.1.257

Phospholipids as the molecular instruments of ion and solute transport in biological membranes.

D E Green, M Fry, G A Blondin
PMCID: PMC348248  PMID: 6928617

Abstract

Partition studies have established that phospholipids generally have the capabilities to mediate the transmembrane transport of the full range of ions and solutes that physiologically cross biological membranes. The list of transportable species includes cations, anions, amino acids, citric acid cycle intermediates, nucleotides, and sugars. Phospholipid-mediated transport can be readily modulated by altering the phospholipid mixture or by addition of detergents, nucleotides, divalent metals, proteins, peptides, or ring compounds. Containment of phospholipid within channels in protein appears to be the precondition for the formation of the micellar structure requisite for solute transport. Phospholipid-mediated transport is postulated to be a central feature of energy coupling, membrane-spanning systems, and membrane-bound, phospholipid-requiring enzymes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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