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. 1980 Jan;77(1):490–493. doi: 10.1073/pnas.77.1.490

Lentropin: a factor in vitreous humor which promotes lens fiber cell differentiation.

D C Beebe, D E Feagans, H A Jebens
PMCID: PMC348297  PMID: 6928641

Abstract

An activity has been identified in chicken vitreous humor which stimulates embryonic chicken lens epithelial cells to elongate and specialize for lens crystallin synthesis. The activity is heat-labile and is destroyed by treatment with trypsin or agents that reduce disulfides. Gel filtration and ultrafiltration analyses indicate that it has an apparent molecular weight of approximately 60,000. Its properties differ from those of an activity present in serum which also can promote lens fiber cell formation in vitro. We call this material "lentropin" and suggest that it is responsible for stimulating lens fiber cell formation in vivo and, consequently, plays an important role in determining the shape and polarity of the lens.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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