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. 1980 Feb;77(2):708–712. doi: 10.1073/pnas.77.2.708

Anticholinergic substances: A single consistent conformation

Peter Pauling 1, Narayandas Datta 1,*
PMCID: PMC348349  PMID: 16592775

Abstract

An interactive computer-graphics analysis of 24 antagonists of acetylcholine at peripheral autonomic post-ganglionic (muscarinic) nervous junctions and at similar junctions in the central nervous system, the crystal structures of which are known, has led to the determination of a single, consistent, energetically favorable conformation for all 24 substances, although their observed crystal structure conformations vary widely. The absolute configuration and the single, consistent (ideal) conformation of the chemical groups required for maximum anticholinergic activity are described quantitatively.

Keywords: acetylcholine, antagonist, absolute configuration, parasympathetic

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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