Abstract
Mutator activity associated with the common male recombination (MR) chromosomes in Drosophila melanogaster appears to be suppressed in natural populations. Crosses between geographically separated populations, however, lead to the release of mutator activity as measured by a significant increase in visible mutations. Such an increase in mutation in hybrid individuals may be a powerful factor in inducing or releasing variation in nature, and in more extreme instances may contribute to the separation of microdifferentiated populations.
Full text
PDF



Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Engels W. R. Extrachromosomal control of mutability in Drosophila melanogaster. Proc Natl Acad Sci U S A. 1979 Aug;76(8):4011–4015. doi: 10.1073/pnas.76.8.4011. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Finnegan D. J., Rubin G. M., Young M. W., Hogness D. S. Repeated gene families in Drosophila melanogaster. Cold Spring Harb Symp Quant Biol. 1978;42(Pt 2):1053–1063. doi: 10.1101/sqb.1978.042.01.106. [DOI] [PubMed] [Google Scholar]
- Green M. M. Genetic instability in Drosophila melanogaster: De novo induction of putative insertion mutations. Proc Natl Acad Sci U S A. 1977 Aug;74(8):3490–3493. doi: 10.1073/pnas.74.8.3490. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Henderson S. A., Woodruff R. C., Thompson J. N. Spontaneous Chromosome Breakage at Male Meiosis Associated with Male Recombination in DROSOPHILA MELANOGASTER. Genetics. 1978 Jan;88(1):93–107. doi: 10.1093/genetics/88.1.93. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hiraizumi Y. Spontaneous recombination in Drosophila melanogaster males. Proc Natl Acad Sci U S A. 1971 Feb;68(2):268–270. doi: 10.1073/pnas.68.2.268. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kastenbaum M. A., Bowman K. O. Tables for determining the statistical significance of mutation frequencies. Mutat Res. 1970 May;9(5):527–549. doi: 10.1016/0027-5107(70)90038-2. [DOI] [PubMed] [Google Scholar]
- Kidwell M. G., Kidwell J. F., Sved J. A. Hybrid Dysgenesis in DROSOPHILA MELANOGASTER: A Syndrome of Aberrant Traits Including Mutation, Sterility and Male Recombination. Genetics. 1977 Aug;86(4):813–833. doi: 10.1093/genetics/86.4.813. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kleckner N. Translocatable elements in procaryotes. Cell. 1977 May;11(1):11–23. doi: 10.1016/0092-8674(77)90313-0. [DOI] [PubMed] [Google Scholar]
- Slatko B. E. Evidence for Newly Induced Genetic Activity Responsible for Male Recombination Induction in DROSOPHILA MELANOGASTER. Genetics. 1978 Sep;90(1):105–124. doi: 10.1093/genetics/90.1.105. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Slatko B. E., Hiraizumi Y. Mutation induction in the male recombination strains of Drosophila melanogaster. Genetics. 1973 Dec;75(4):643–649. doi: 10.1093/genetics/75.4.643. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sochacka J. H., Woodruff R. C. Induction of male recombination in Drosophila melanogaster by injection of extracts of flies showing male recombination. Nature. 1976 Jul 22;262(5566):287–289. doi: 10.1038/262287a0. [DOI] [PubMed] [Google Scholar]
- Strobel E., Dunsmuir P., Rubin G. M. Polymorphisms in the chromosomal locations of elements of the 412, copia and 297 dispersed repeated gene families in Drosophila. Cell. 1979 Jun;17(2):429–439. doi: 10.1016/0092-8674(79)90169-7. [DOI] [PubMed] [Google Scholar]
- Sturtevant A. H. High Mutation Frequency Induced by Hybridization. Proc Natl Acad Sci U S A. 1939 Jul;25(7):308–310. doi: 10.1073/pnas.25.7.308. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Thompson J. N., Jr, Woodruff R. C. Mutator genes--pacemakers of evolution. Nature. 1978 Jul 27;274(5669):317–321. doi: 10.1038/274317a0. [DOI] [PubMed] [Google Scholar]
- Woodruff R. C., Thompson J. N., Jr, Lyman R. F. Intraspecific hybridisation and the release of mutator activity. Nature. 1979 Mar 15;278(5701):277–279. doi: 10.1038/278277a0. [DOI] [PubMed] [Google Scholar]