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. 1980 Apr;77(4):2178–2182. doi: 10.1073/pnas.77.4.2178

In vivo or in vitro treatments with anti-I-J alloantisera abolish immunity to AKR leukemia.

D Meruelo, N Flieger, D Smith, H O McDevitt
PMCID: PMC348675  PMID: 6769122

Abstract

This paper provides evidence for the involvement of immune mechanisms in conferring resistance to a spontaneous AKR leukemia. It is shown that genes in the B, J, or E subregions of the H-2 complex confer resistance to a spontaneously arisen, tissue culture-adapted AKR thymoma, BW5147. A direct correlation is demonstrated between survival to injected BW5147 cells and humoral responsiveness in various hybrids obtained from crosses of AKR mice and C57BL/10 or C3H/DiSn derived congeneic strains differing at H-2. Cellular immunity appears to play no role in resistance to the proliferation of tumor cells. It is further established that development of effective humoral immunity depends on B cells and Ly-1+, 2-, 3- helper T-cells bearing the I-Jk phenotype. These findings seem directly applicable to the spontaneous disease, and results of studies using transformed cells from an overtly leukemic AKR mouse parallel those obtained using BW1547 cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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