Skip to main content
NCBI home page
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1980 Apr;77(4):2244–2246. doi: 10.1073/pnas.77.4.2244

Expression of peanut agglutinin receptors on virus-induced preleukemic cells in mice.

Y Reisner, N Sharon, N Haran-Ghera
PMCID: PMC348689  PMID: 6246529

Abstract

Preleukemic bone marrow and spleen cells of irradiated C57BL/6 mice that were inoculated with the radiation-induced leukemia virus variant D-RadLV differ from autonomous end-stage leukemia cells in the expression of the receptor for peanut agglutinin. As a result, the preleukemic cells are agglutinated by peanut agglutinin and the end-stage cells are not. This observation provides further evidence that preleukemic cells possess surface markers similar to those of the prothymocyte. In vitro and in vivo thymocyte-virus interactions reveal that cells susceptible to D-RadLV transformation are present mainly among the peanut agglutinin-receptor-bearing thymocyte population which has previously been demonstrated to be immunologically immature.

Full text

PDF
2244

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Chazan R., Haran-Ghera N. The role of thymus subpopulations in "T" leukemia development. Cell Immunol. 1976 May;23(2):356–375. doi: 10.1016/0008-8749(76)90200-8. [DOI] [PubMed] [Google Scholar]
  2. Danon D., Marikovsky Y., Kohn A. Red cell agglutination kinetics: a method for automatic recording with the fragiligraph. Experientia. 1969 Jan 15;25(1):104–106. doi: 10.1007/BF01903926. [DOI] [PubMed] [Google Scholar]
  3. Haran-Ghera N., Ben-Yaakov M., Peled A. Immunologic characteristics in relation to high and low leukemogenic activity of radiation leukemia virus variants. I. Cellular analysis of immunosuppression. J Immunol. 1977 Feb;118(2):600–606. [PubMed] [Google Scholar]
  4. Haran-Ghera N. Relationship between tumour cell and host in chemical leukaemogenesis. Nat New Biol. 1973 Nov 21;246(151):84–86. doi: 10.1038/newbio246084a0. [DOI] [PubMed] [Google Scholar]
  5. Haran-Ghera N., Rubio N., Leef F., Goldstein G. Characteristics of preleukemia cells induced in mice. Cell Immunol. 1978 May;37(2):308–314. doi: 10.1016/0008-8749(78)90199-5. [DOI] [PubMed] [Google Scholar]
  6. Haran-Ghera N. Spontaneous and induced preleukemia cells in C57BL/6 mice:brief communication. J Natl Cancer Inst. 1978 Mar;60(3):707–710. doi: 10.1093/jnci/60.3.707. [DOI] [PubMed] [Google Scholar]
  7. London J., Berrih S., Bach J. F. Peanut agglutinin. I. A new tool for studying T lymphocyte subpopulations. J Immunol. 1978 Aug;121(2):438–443. [PubMed] [Google Scholar]
  8. Lotan R., Skutelsky E., Danon D., Sharon N. The purification, composition, and specificity of the anti-T lectin from peanut (Arachis hypogaea). J Biol Chem. 1975 Nov 10;250(21):8518–8523. [PubMed] [Google Scholar]
  9. Nicolson G. L. Trans-membrane control of the receptors on normal and tumor cells. II. Surface changes associated with transformation and malignancy. Biochim Biophys Acta. 1976 Apr 30;458(1):1–72. doi: 10.1016/0304-419x(76)90014-7. [DOI] [PubMed] [Google Scholar]
  10. Rabinovich H., Umiel T., Reisner Y., Sharon N., Globerson A. Characterization of embryonic liver suppressor cells by peanut agglutinin. Cell Immunol. 1979 Oct;47(2):347–355. doi: 10.1016/0008-8749(79)90344-7. [DOI] [PubMed] [Google Scholar]
  11. Rapin A. M., Burger M. M. Tumor cell surfaces: general alterations detected by agglutinins. Adv Cancer Res. 1974;20:1–91. doi: 10.1016/s0065-230x(08)60108-6. [DOI] [PubMed] [Google Scholar]
  12. Reisner Y., Biniaminov M., Rosenthal E., Sharon N., Ramot B. Interaction of peanut agglutinin with normal human lymphocytes and with leukemic cells. Proc Natl Acad Sci U S A. 1979 Jan;76(1):447–451. doi: 10.1073/pnas.76.1.447. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Reisner Y., Ikehara S., Hodes M. Z., Good R. A. Allogeneic hemopoietic stem cell transplantation using mouse spleen cells fractionated by lectins: in vitro study of cell fractions. Proc Natl Acad Sci U S A. 1980 Feb;77(2):1164–1168. doi: 10.1073/pnas.77.2.1164. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Reisner Y., Itzicovitch L., Meshorer A., Sharon N. Hemopoietic stem cell transplantation using mouse bone marrow and spleen cells fractionated by lectins. Proc Natl Acad Sci U S A. 1978 Jun;75(6):2933–2936. doi: 10.1073/pnas.75.6.2933. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Reisner Y., Linker-Israeli M., Sharon N. Separation of mouse thymocytes into two subpopulations by the use of peanut agglutinin. Cell Immunol. 1976 Jul;25(1):129–134. doi: 10.1016/0008-8749(76)90103-9. [DOI] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES