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. 1980 Apr;77(4):2303–2304. doi: 10.1073/pnas.77.4.2303

Beta-Endorphin: dissociation of receptor binding activity from analgesic potency.

C H Li, L F Tseng, P Ferrara, D Yamashiro
PMCID: PMC348702  PMID: 6246537

Abstract

Biological activities of synthetic camel beta-endorphin and human beta-endorphin (beta h-EP) have been measured by the radioreceptor binding assay, using [Tyr27-3H]-beta h-EP as the primary ligand and by the tail-flick test for analgesic potency. Four synthetic analogs of beta h-EP, namely [Gly31]-beta h-EP-Gly-NH2, [Gly31]-beta h-EP-Gly-Gly-NH2, [Gln8,Gly31]-beta h-EP-Gly-Gly-NH2, and [CH3(CH2)4NH231]-beta h-EP, have also been assayed by the same procedures. Results indicate a clear dissociation of radioreceptor binding activity from analgesic potency.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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