Skip to main content
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1981 Sep;78(9):5275–5278. doi: 10.1073/pnas.78.9.5275

Molecular engineering: An approach to the development of general capabilities for molecular manipulation

K Eric Drexler 1
PMCID: PMC348724  PMID: 16593078

Abstract

Development of the ability to design protein molecules will open a path to the fabrication of devices to complex atomic specifications, thus sidestepping obstacles facing conventional microtechnology. This path will involve construction of molecular machinery able to position reactive groups to atomic precision. It could lead to great advances in computational devices and in the ability to manipulate biological materials. The existence of this path has implications for the present.

Keywords: molecular machinery, protein design, synthetic chemistry, computation, tissue characterization

Full text

PDF
5275

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Drake J. W., Allen E. F., Forsberg S. A., Preparata R. M., Greening E. O. Genetic control of mutation rates in bacteriophageT4. Nature. 1969 Mar 22;221(5186):1128–1132. [PubMed] [Google Scholar]
  2. Gund P., Andose J. D., Rhodes J. B., Smith G. M. Three-dimensional molecular modeling and drug design. Science. 1980 Jun 27;208(4451):1425–1431. doi: 10.1126/science.6104357. [DOI] [PubMed] [Google Scholar]
  3. Gutte B., Däumigen M., Wittschieber E. Design, synthesis and characterisation of a 34-residue polypeptide that interacts with nucleic acids. Nature. 1979 Oct 25;281(5733):650–655. doi: 10.1038/281650a0. [DOI] [PubMed] [Google Scholar]
  4. Itakura K., Riggs A. D. Chemical DNA synthesis and recombinant DNA studies. Science. 1980 Sep 19;209(4463):1401–1405. doi: 10.1126/science.6106285. [DOI] [PubMed] [Google Scholar]
  5. Karplus M., Weaver D. L. Protein-folding dynamics. Nature. 1976 Apr 1;260(5550):404–406. doi: 10.1038/260404a0. [DOI] [PubMed] [Google Scholar]
  6. McCammon J. A., Gelin B. R., Karplus M. Dynamics of folded proteins. Nature. 1977 Jun 16;267(5612):585–590. doi: 10.1038/267585a0. [DOI] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES