Table 1.

Culture performance in parallel ambr™, 2-L bioreactors, and shake flasks for four cell lines

Cell line	Vessel	Maximumd growth ratee (1/d)	Day 14 titer (g/L)e	Cell-specific productivity (pg/cell/d)e
1	ambr™a	0.38 ± 0.01	1.22 ± 0.02	7.2 ± 0.3
	2-L Bioreactorb	0.38 ± 0.01	1.16 ± 0.09	6.4 ± 0.5
	Shake flaskc	0.28 ± 0.01	1.50 ± 0.05	12.6 ± 0.5
2	ambr™a	0.35 ± 0.00	1.94 ± 0.04	7.6 ± 0.2
	2-L Bioreactorb	0.33 ± 0.00	1.92 ± 0.11	7.7 ± 0.5
	Shake flaskc	0.26 ± 0.00	2.16 ± 0.00	12.8 ± 0.6
3	ambr™a	0.39 ± 0.01	2.71 ± 0.01	14.1 ± 0.3
	2-L Bioreactorb	0.35 ± 0.02	2.85 ± 0.05	13.4 ± 0.4
	Shake flaskc	0.35 ± 0.01	3.27 ± 0.11	17.2 ± 0.0
4	ambr™a	0.34 ± 0.01	2.41 ± 0.07	13.5 ± 0.6
	2-L Bioreactorb	0.35 ± 0.01	2.92 ± 0.13	15.2 ± 0.2
	Shake flaskc	0.28 ± 0.01	1.70 ± 0.00	15.0 ± 0.2

^an = 6

^bn = 2

^cn = 2

^dMeasured from days 0–7

^eAverage ±1 standard deviation