. Author manuscript; available in PMC: 2013 Nov 25.

Published in final edited form as: Virology. 2012 Sep 18;433(2):410–420. doi: 10.1016/j.virol.2012.08.033

Table 3. Effects of single point mutations on neutralization sensitivity and summary of antibody specificities.

Plasma sample identity	Fold effect of mutation^a									Antibody specificity conferring breadth
Plasma sample identity		ConC N160A	ConC I165A	ConC K169E	CAP45 N160A	CAP45 I165A	CAP45.G3 K169E	Du156.12 N332A	Q23.17 N332A	Antibody specificity conferring breadth	Tro.11 N332A
SK200	1.1	0.5	0.7	1.0	0.6	1.9	1.2	1.5	0	Unknown
study exit SK221	0.4	0.3	1.1	2.0	0.4	5.6	1.4	0.6	4.2	Quaternary, PG9/PG16 like, N332
study exit SK233 study exit	0.1	0	0.6	0.8	0.9	4	0.7	1.2	0	Quaternary, PG9/PG16 like

Calculated as wild type IC₅₀/mutant IC₅₀ for the plasma. Changes in titer of >3 fold are shown in bold.