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. 1981 Sep;78(9):5852–5855. doi: 10.1073/pnas.78.9.5852

Pleiotropic expression of Epstein--Barr virus DNA in human epithelial cells.

J Stoerker, D Parris, Y Yajima, R Glaser
PMCID: PMC348885  PMID: 6272321

Abstract

We have attempted to establish a system that can be used to study the association of Epstein--Barr virus (EBV) with epithelial cells. Attempts were made to transfect human carcinoma cells with EBV DNA. Successful transfection was confirmed by the expression of EBV-specific early antigen (EA), virus capsid antigen, and the presence of virus DNA. The transfecting preparation contained a mixture of EBV and cellular DNA extracted from two producer cell lines, P3HR-1 and AG-876. Our data suggest that virus DNA obtained from the P3HR-1 nontransforming, EA-inducing strain of EBV was lytically expressed in the epithelial tumor cells. The DNA derived from AG-876 cells, which produce a transforming, non-EA-inducing strain of EBV, also produced a lytic infection.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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