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. Author manuscript; available in PMC: 2012 Nov 5.
Published in final edited form as: Virology. 2009 Jun 6;390(2):174–185. doi: 10.1016/j.virol.2009.05.011

Figure 7. Inhibition of KSHV-induced transformation.

Figure 7

To investigate whether the kinases in the c-Kit signaling pathway are involved in KSHV-induced transformation of EC, inhibitors at either 0.5μM (A, top panels) or 2μM (A, bottom panels and B) were added to mock and KSHV-infected eDMVECs (21 days post infection). Media plus inhibitor was changed every 2-3 days. After 8 days the cells were (A) photographed live to record any changes in the spindle cell morphology and then (B) fixed and stained with ORF73 antibodies to assess any alterations in the level of viral infection. (B, top panels) ORF73 immunofluorescence (B, bottom panels) corresponding phase images.