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. 1981 Oct;78(10):6173–6175. doi: 10.1073/pnas.78.10.6173

Preparation of tritium- or deuterium-labeled vitamin D analogs by a convenient general method*

Herbert E Paaren 1, Mary A Fivizzani 1, Heinrich K Schnoes 1, Hector F DeLuca 1
PMCID: PMC349000  PMID: 6273856

Abstract

The three-step conversion of vitamin D analogs to 6-oxo-3,5-cyclovitamin D derivatives followed by reduction with a tritide or deuteride reagent and subsequent cycloreversion gives 6-tritio(deutero)vitamin D derivatives and corresponding 5,6-trans-analogs. The method is general and affords the 6-labeled-vitamin D analogs in ≈20% overall yield.

Keywords: calcium, labeled vitamin D, calciferol, bone

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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