Abstract
A basic question about visual perception is whether the retina produces a faithful or a distorted neural representation of the visual image. It is now well known that in some retinal pathways there are significant nonlinear transductions which distort the neural image. The next natural question is, What are the locations of the nonlinear stages within the retinal network? We report here on an investigation of linearity and nonlinearity of responses of horizontal cells in the turtle retina as an assay of the degree of nonlinearity in the outer plexiform layer of the retina. The visual stimuli were sinusoidal gratings; these patterns were modulated by contrast reversal with a sinusoidal time course. The conclusion from our experiments is that the turtle's horizontal cell responses show evidence only of linear spatial summation even at moderately high contrasts on moderately high background levels. Our work thus indicates that there is no significant distortion of the visual image by the photoreceptors or by the neural summation of photoreceptor signals by horizontal cells under normal physiological conditions. These results are consistent with the view that the major nonlinearities of the retina are proximal to the outer plexiform layer.
Full text
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Baylor D. A., Fettiplace R. Synaptic drive and impulse generation in ganglion cells of turtle retina. J Physiol. 1979 Mar;288:107–127. [PMC free article] [PubMed] [Google Scholar]
- Baylor D. A., Hodgkin A. L., Lamb T. D. The electrical response of turtle cones to flashes and steps of light. J Physiol. 1974 Nov;242(3):685–727. doi: 10.1113/jphysiol.1974.sp010731. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bowling D. B. Light responses of ganglion cells in the retina of the turtle. J Physiol. 1980 Feb;299:173–196. doi: 10.1113/jphysiol.1980.sp013118. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Brodie S. E., Knight B. W., Ratliff F. The spatiotemporal transfer function of the Limulus lateral eye. J Gen Physiol. 1978 Aug;72(2):167–202. doi: 10.1085/jgp.72.2.167. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Davis G. W., Naka K. Spatial organization of catfish retinal neurons. I. Single- and random-bar stimulation. J Neurophysiol. 1980 Mar;43(3):807–831. doi: 10.1152/jn.1980.43.3.807. [DOI] [PubMed] [Google Scholar]
- Enroth-Cugell C., Robson J. G. The contrast sensitivity of retinal ganglion cells of the cat. J Physiol. 1966 Dec;187(3):517–552. doi: 10.1113/jphysiol.1966.sp008107. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Foerster M. H., van de Grind W. A., Grüsser O. J. The response of cat horizontal cells to flicker stimuli of different area, intensity and frequency. Exp Brain Res. 1977 Sep 28;29(3-4):367–385. doi: 10.1007/BF00236176. [DOI] [PubMed] [Google Scholar]
- Fuortes M. G., Schwartz E. A., Simon E. J. Colour-dependence of cone responses in the turtle retina. J Physiol. 1973 Oct;234(1):199–216. doi: 10.1113/jphysiol.1973.sp010341. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fuortes M. G., Simon E. J. Interactions leading to horizontal cell responses in the turtle retina. J Physiol. 1974 Jul;240(1):177–198. doi: 10.1113/jphysiol.1974.sp010606. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hochstein S., Shapley R. M. Quantitative analysis of retinal ganglion cell classifications. J Physiol. 1976 Nov;262(2):237–264. doi: 10.1113/jphysiol.1976.sp011594. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Krausz H. I., Naka K. Spatiotemporal testing and modeling of catfish retinal neurons. Biophys J. 1980 Jan;29(1):13–36. doi: 10.1016/S0006-3495(80)85115-0. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lamb T. D. Spatial properties of horizontal cell responses in the turtle retina. J Physiol. 1976 Dec;263(2):239–255. doi: 10.1113/jphysiol.1976.sp011630. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Marmarelis P. Z., Naka K. I. Nonlinear analysis and synthesis of receptive-field responses in the catfish retina. II. One-input white-noise analysis. J Neurophysiol. 1973 Jul;36(4):619–633. doi: 10.1152/jn.1973.36.4.619. [DOI] [PubMed] [Google Scholar]
- Marmarelis P. Z., Naka K. I. Spatial distribution of potential in a flat cell. Application to the catfish horizontal cell layers. Biophys J. 1972 Nov;12(11):1515–1532. doi: 10.1016/S0006-3495(72)86179-4. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Naka K. I., Rushton W. A. The generation and spread of S-potentials in fish (Cyprinidae). J Physiol. 1967 Sep;192(2):437–461. doi: 10.1113/jphysiol.1967.sp008308. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Normann R. A., Perlman I. Signal transmission from red cones to horizontal cells in the turtle retina. J Physiol. 1979 Jan;286:509–524. doi: 10.1113/jphysiol.1979.sp012634. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Perlman I., Normann R. A. Short-wavelength input to luminosity-type horizontal cells in the turtle retina. Vision Res. 1979;19(8):903–906. doi: 10.1016/0042-6989(79)90024-5. [DOI] [PubMed] [Google Scholar]
- Schwartz E. A. Organization of on-off cells in the retina of the turtle. J Physiol. 1973 Apr;230(1):1–14. doi: 10.1113/jphysiol.1973.sp010171. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shapley R. M., Gordon J. The eel retina. Ganglion cell classes and spatial mechanisms. J Gen Physiol. 1978 Feb;71(2):139–155. doi: 10.1085/jgp.71.2.139. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Simon E. J. Two types of luminosity horizontal cells in the retina of the turtle. J Physiol. 1973 Apr;230(1):199–211. doi: 10.1113/jphysiol.1973.sp010183. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Spekreijse H., Norton A. L. The dynamic characteristics of color-coded S-potentials. J Gen Physiol. 1970 Jul;56(1):1–15. doi: 10.1085/jgp.56.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Toyoda J. Frequency characteristics of retinal neurons in the carp. J Gen Physiol. 1974 Feb;63(2):214–234. doi: 10.1085/jgp.63.2.214. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Victor J. D., Shapley R. M. The nonlinear pathway of Y ganglion cells in the cat retina. J Gen Physiol. 1979 Dec;74(6):671–689. doi: 10.1085/jgp.74.6.671. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Yazulla S. Cone input to horizontal cells in the turtle retina. Vision Res. 1976;16(7):727–735. doi: 10.1016/0042-6989(76)90183-8. [DOI] [PubMed] [Google Scholar]