Table 2.
Effect of hyperglycemia on plasma and artery lipids in control and STZ-DM monkeysa
| Control (n=10) | STZ-DM (n=10) | p-value | |
|---|---|---|---|
| Plasma lipids | |||
| Total cholesterol (mg/dl) | 233 ± 25 | 270 ± 32 | 0.91 |
| ApoB cholesterol (mg/dl) | 189 ± 29 | 227 ± 35 | 0.94 |
| HDL cholesterol (mg/dl) | 45 ± 5 | 43 ± 5 | 0.74 |
| Triglycerides (mg/dl) | 32 ± 4 | 152 ± 58 | <0.05 |
| Free fatty acids (mEq/l) | 0.68 ± 0.10 | 0.80 ± 0.16 | 0.72 |
| Carotid artery lipids | |||
| Total cholesterol (μg/mg protein) | 10.6 ± 3.2 | 14.2 ± 6.5 | 0.63 |
| Free cholesterol (μg/mg protein) | 5.9 ± 1.0 | 6.4 ± 2.4 | 0.85 |
| Cholesterol ester (μg/mg protein) | 5.5 ± 2.2 | 8.0 ± 4.1 | 0.53 |
| Lipid peroxides (nmol/mg) | 5.06 ± 1.24 | 4.73 ± 1.72 | 0.58 |
| Aortic intimal area (mm2) | 0.86 ± 0.30 | 0.83 ± 0.33 | 0.94 |
a
Fasting blood samples and carotid artery lipids were obtained from control and streptozotocin-treated monkeys four weeks after diabetes induction. Aortic intimal area was determined by computer morphometric analysis. Data are presented as the mean ± SEM (n = 10 animals per group) together with respective T-test or ANCOVA p-values.