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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1981 Nov;78(11):7111–7114. doi: 10.1073/pnas.78.11.7111

In vivo effects of antibodies to immune response gene products: prevention of experimental allergic encephalitis.

L Steinman, J T Rosenbaum, S Sriram, H O McDevitt
PMCID: PMC349205  PMID: 6947275

Abstract

Prevention of experimental allergic encephalitis in SJL/J [H-2s] mice was achieved with in vivo administration of antibody reactive with I-As gene products prior to immunization with spinal cord antigen. No protection was evident in animals that received antisera specific for I-Js gene products. Administration of antibody to I-As beginning 5 days after immunization with spinal cord antigen delayed, but did not prevent, the onset of experimental allergic encephalitis.

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Selected References

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