Table 2.
Ingenuity Pathway Analysis of genes correlated with miR-122 expression in HCC
| Positive correlation | Negative correlation |
|---|---|
| Disease and disorders | |
| Hepatic system disease (P<10−6) | Cancer (P<10−9) |
| Molecular and cellular functions | |
| Lipid metabolism (P<10−9) | Cell cycle (P<10−5) |
| Amino acid metabolism (P<10−3) | Cell. assembly & org. (P<10−5) |
| Physiological system development and functions | |
| Tumor morphology (P<10−3) | Immune response (P<10−3) |
| Embryonic development (P<10−3) | Connective tissue dev. (P<10−3) |
| Tumor morphology (P<10−3) | |
| Top canonical pathways | |
| Fatty acid metabolism (P<10−10) | Actin cystosk. Signaling (P<10−4) |
| Xenobiotic metabolism (P<10−5) | Hypoxia signaling (P<10−3) |
| Coagulation system (P<10−5) | |
| FXR/ RXR Activation (P<10−4) | |
| Top Tox functions: Hepatotoxicity | |
| Liver cholestasis (P<10−6) | Hepatocellular carcinoma (P<10−3) |