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A. Mechanism of GCL reaction, including tautomerization/ionization states of thiamin. The possible reactions of a decarboxylase-carboligase with glyoxylate. B. The possible reactions of a decarboxylase-carboligase with pyruvate as sole substrates, acetolactate is produced. With the I393A GCL, in the presence of pyruvate and glyoxylate the mixed product acetylglycolic acid is the expected product.
