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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1981 Dec;78(12):7689–7691. doi: 10.1073/pnas.78.12.7689

Neonatal tolerance to alloantigens alters major histocompatibility complex-restricted response patterns.

A Müllbacher
PMCID: PMC349335  PMID: 6977774

Abstract

Male-specific transplantation antigen (H-Y)-immune cytotoxic T cells of some individual CBA/H mice exhibit lytic activity on male and female allogeneic targets (e.g., H-2b). Neonatal tolerance to H-2b abrogates the ability of CBA mice to generate secondary H-Y-immune cytotoxic T cells, but such cell activity to third-party alloantigens and to Bebaru and influenza virus is not impaired. The results are discussed in relationship to dominant major histocompatibility complex-coded immune response gene effects on cytotoxic T-cell responses.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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