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. 1981 Dec;78(12):7769–7772. doi: 10.1073/pnas.78.12.7769

Proline and glucose transport by renal membranes from dogs with spontaneous idiopathic Fanconi syndrome.

M S Medow, R Reynolds, K C Bovee, S Segal
PMCID: PMC349352  PMID: 6950417

Abstract

The uptake of proline and glucose by renal brush border membrane vesicles isolated from Basenji dogs exhibiting a spontaneous Fanconi syndrome was examined. The magnitude of the 1-min, Na+-gradient uptake of proline (0.02 mM) and glucose (1.0 mM) by vesicles from affected dog kidney was lower than normal. Concentration-dependent 15-sec uptake in vesicles from normal and affected dogs reveals a two-component transport system for proline and glucose. Kinetic analysis shows altered Km and Vmax values for both proline and glucose transport in the affected dogs. The data suggest that, in this model of Fanconi syndrome, the defective renal reabsorption of proline and glucose is associated with an alteration of luminal transport system.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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