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. 1980 May;77(5):2429–2433. doi: 10.1073/pnas.77.5.2429

Multiple methylation in processing of sensory signals during bacterial chemotaxis.

A L DeFranco, D E Koshland Jr
PMCID: PMC349412  PMID: 6446711

Abstract

The multiple banding pattern on NaDodSO4/polyacrylamide electrophoresis of a subset of the signal transduction proteins involved in bacterial chemotaxis has been shown to be caused by multiple methylation of a single gene product. At least four methyl groups are introduced per molecule of the sensing membrane protein to give a total of five bands. The separation of the bands appears to correspond to a Mr difference of 1500, probably caused by the binding of different amounts of DodSO4 molecules as carboxyl groups are modified. Multiple methylation, similar to multiple phosphorylation in other systems, appears to offer advantages in control and sensory processing.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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