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. 1980 May;77(5):2626–2630. doi: 10.1073/pnas.77.5.2626

Acetate kinase: a triple-displacement enzyme.

L B Spector
PMCID: PMC349455  PMID: 6248856

Abstract

Facts relating to the mechanism of phosphoryl transfer by acetate kinase (ATP:acetate phosphotransferase, EC 2.7.2.1) are reviewed. They point to the existence of at least one experimentally established phosphoenzyme (E-P) intermediate on the reaction pathway. Sterically, the phosphoryl transfer occurs with a net inversion of the configuration of the phosphorus atom. These facts are best in accord with a triple-displacement mode of action for acetate kinase, with two E-P intermediates and three steric inversions on phosphorus. It follows that a second E-P for acetate kinase must exist.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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