Table 2. Median (interquartile range) binding globulin levels.

Group	Non-users	Inconsistent users	Compliant users	P*	P**	P***
N	12	9	42
CBG (mcg/mL)
Baseline	55.0 (50.0, 58.8)	52.5 (40.0, 55.0)	55.0 (47.5, 60.0)	0.33	0.97	0.15
Follow-up	58.8 (53.8, 68.8)	90.0 (67.5, 102.5)	107.5 (95.0, 120.0)	<0.001	<0.001	0.004
Change	1.3 (-3.8, 8.8)	32.5 (17.5, 55.0)	52.5 (40.0, 65.0)	<0.001	<0.001	0.077
% change	2.5 (-4.0, 15.5)	57.0 (47.0, 137.0)	92.5 (70.0, 138.0)	<0.001	<0.001	0.29
TBG (mcg/mL)
Baseline	24.4 (21.7, 28.0)	20.3 (18.3, 21.7)	22.1 (19.2, 24.5)	0.035	0.072	0.17
Follow-up	25.6 (21.7, 30.5)	21.5 (20.4, 23.3)	31.7 (27.3, 38.4)	0.001	0.015	0.002
Change	1.5 (-1.2, 4.6)	3.0 (0.6, 6.9)	11.0 (7.7, 13.9)	<0.001	<0.001	0.002
% change	6.0 (-4.5, 16.3)	15.1 (2.6, 34.0)	51.1 (34.0, 64.4)	<0.001	<0.001	0.005
SHBG (nmol/L)
Baseline	44.0 (32.2, 61.6)	32.0 (27.9, 47.3)	45.2 (37.4, 69.7)	0.45	0.89	0.24
Follow-up	48.1 (35.2, 79.4)	60.5 (34.3, 74.1)	80.1 (63.3, 97.4)	0.009	0.022	0.012
Change	3.7 (-6.3, 26.6)	5.0 (-7.1, 27.2)	30.1 (13.0, 40.9)	0.045	0.034	0.088
% change	8.4 (-10.6, 48.2)	30.9 (-10.5, 104)	70.1 (19.6, 104.5)	0.01	0.003	0.22

^*Kruskal Wallis non-parametric analysis of variance (2 d.f.).

^**Nonusers versus compliant users.

^***Inconsistent users versus compliant users.