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. 1980 May;77(5):2886–2889. doi: 10.1073/pnas.77.5.2886

Presence of allograft-rejection resistance in simian virus 40-transformed hamster cells and its possible role in tumor development.

A M Lewis Jr, J L Cook
PMCID: PMC349510  PMID: 6248874

Abstract

LSH Syrian hamster cells transformed in vitro by simian virus 40, which is oncogenic for hamsters, are resistant to rejection by adult allogeneic CB hamsters. In contrast, simian virus 40-transformed cells from other species are usually not oncogenic in immunocompetent autologous or isologous hosts. The ability of simian virus 40 to convey resistance to an allograft-type host response to transformed hamster cells may be important in determining the tumor-inducing capacity of these cells and could, in part, explain the species-specific oncogenicity of this virus.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BLACK P. H., ROWE W. P. SV-40 INDUCED PROLIFERATION OF TISSUE CULTURE CELLS OF RABBIT, MOUSE, AND PORCINE ORIGIN. Proc Soc Exp Biol Med. 1963 Dec;114:721–727. doi: 10.3181/00379727-114-28780. [DOI] [PubMed] [Google Scholar]
  2. Billingham R. E., Sawchuck G. H., Silvers W. K. STUDIES ON THE HISTOCOMPATIBILITY GENES OF THE SYRIAN HAMSTER. Proc Natl Acad Sci U S A. 1960 Aug;46(8):1079–1090. doi: 10.1073/pnas.46.8.1079. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Brugge J. S., Butel J. S. Role of simian virus 40 gene A function in maintenance of transformation. J Virol. 1975 Mar;15(3):619–635. doi: 10.1128/jvi.15.3.619-635.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Butel J. S., Tevethia S. S., Melnick J. L. Oncogenicity and cell transformation by papovavirus SV40: the role of the viral genome. Adv Cancer Res. 1972;15:1–55. doi: 10.1016/s0065-230x(08)60371-1. [DOI] [PubMed] [Google Scholar]
  5. Cook J. L., Lewis A. M., Jr Host response to adenovirus 2-transformed hamster embryo cells. Cancer Res. 1979 May;39(5):1455–1461. [PubMed] [Google Scholar]
  6. Duncan W. R., Streilein J. W. Analysis of the major histocompatibility complex in Syrian hamsters. I. Skin graft rejection, graft-versus-host reactions, mixed lymphocyte reactions, and immune response genes in inbred strains. Transplantation. 1978 Jan;25(1):12–16. [PubMed] [Google Scholar]
  7. Duncan W. R., Streilein J. W. Analysis of the major histocompatibility complex in Syrian hamsters. II. Linkage studies. Transplantation. 1978 Jan;25(1):17–22. doi: 10.1097/00007890-197801000-00004. [DOI] [PubMed] [Google Scholar]
  8. EDDY B. E., BORMAN G. S., GRUBBS G. E., YOUNG R. D. Identification of the oncogenic substance in rhesus monkey kidney cell culture as simian virus 40. Virology. 1962 May;17:65–75. doi: 10.1016/0042-6822(62)90082-x. [DOI] [PubMed] [Google Scholar]
  9. EDDY B. E. SIMIAN VIRUS 40 (SV-40): AN ONCOGENIC VIRUS. Prog Exp Tumor Res. 1964;4:1–26. doi: 10.1159/000385971. [DOI] [PubMed] [Google Scholar]
  10. Fiers W., Contreras R., Haegemann G., Rogiers R., Van de Voorde A., Van Heuverswyn H., Van Herreweghe J., Volckaert G., Ysebaert M. Complete nucleotide sequence of SV40 DNA. Nature. 1978 May 11;273(5658):113–120. doi: 10.1038/273113a0. [DOI] [PubMed] [Google Scholar]
  11. Fluck M. M., Benjamin T. L. Comparisons of two early gene functions essential for transformation in polyoma virus and SV-40. Virology. 1979 Jul 15;96(1):205–228. doi: 10.1016/0042-6822(79)90185-5. [DOI] [PubMed] [Google Scholar]
  12. Freeman A. E., Calisher C. H., Price P. J., Turner H. C., Huebner R. J. Calcium sensitivity of cell cultures derived from adenovirus-induced tumors. Proc Soc Exp Biol Med. 1966 Jul;122(3):835–840. doi: 10.3181/00379727-122-31264. [DOI] [PubMed] [Google Scholar]
  13. Hargis B. J., Malkiel S. Sarcomas induced by injection of simian virus 40 into neonatal CFW mice. J Natl Cancer Inst. 1979 Oct;63(4):965–968. [PubMed] [Google Scholar]
  14. Johansson K., Persson H., Lewis A. M., Pettersson U., Tibbetts C., Philipson L. Viral DNA sequences and gene products in hamster cells transformed by adenovirus type 2. J Virol. 1978 Sep;27(3):628–639. doi: 10.1128/jvi.27.3.628-639.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Kit S., Kurimura T., Dubbs D. R. Transplantable mouse tumor line induced by injection of SV40-transformed mouse kidney cells. Int J Cancer. 1969 Jul 15;4(4):384–392. doi: 10.1002/ijc.2910040403. [DOI] [PubMed] [Google Scholar]
  16. Law L. W., Takemoto K. K., Rogers M. J., Henriksen O., Ting R. C. Differences in the capacity of simian virus 40 (SV40) tumor antigens on cells, membranes and in soluble form to induce transplantation immunity in hamsters and mice. Int J Cancer. 1978 Sep 15;22(3):315–322. doi: 10.1002/ijc.2910220315. [DOI] [PubMed] [Google Scholar]
  17. Lewis A. M., Jr, Cook J. L. Association of tumor induction by ultraviolet light-inactivated adenovirus 2-simian virus 40 recombinants with a specific segment of simian virus 40 DNA. J Natl Cancer Inst. 1979 Sep;63(3):695–705. doi: 10.1093/jnci/63.3.695. [DOI] [PubMed] [Google Scholar]
  18. Lewis A. M., Jr, Martin R. G. Oncogenicity of simian virus 40 deletion mutants that induce altered 17-kilodalton t-proteins. Proc Natl Acad Sci U S A. 1979 Sep;76(9):4299–4302. doi: 10.1073/pnas.76.9.4299. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Martin R. G., Chou J. Y. Simian virus 40 functions required for the establishment and maintenance of malignant transformation. J Virol. 1975 Mar;15(3):599–612. doi: 10.1128/jvi.15.3.599-612.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. McAllister R. M., Nicolson M. O., Reed G., Kern J., Gilden R. V., Huebner R. J. Transformation of rodent cells by adenovirus 19 and other group D adenoviruses. J Natl Cancer Inst. 1969 Oct;43(4):917–923. [PubMed] [Google Scholar]
  21. Osborn M., Weber K. Simian virus 40 gene A function and maintenance of transformation. J Virol. 1975 Mar;15(3):636–644. doi: 10.1128/jvi.15.3.636-644.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Prives C., Gilboa E., Revel M., Winocour E. Cell-free translation of simian virus 40 early messenger RNA coding for viral T-antigen. Proc Natl Acad Sci U S A. 1977 Feb;74(2):457–461. doi: 10.1073/pnas.74.2.457. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. RABSON A. S., O'CONOR G. T., KIRSCHSTEIN R. L., BRANIGAN W. J. Papillary ependymomas produced in Rattus (Mastomys) natalensis inoculated with vacuolating virus (SV40). J Natl Cancer Inst. 1962 Oct;29:765–787. [PubMed] [Google Scholar]
  24. Reddy V. B., Thimmappaya B., Dhar R., Subramanian K. N., Zain B. S., Pan J., Ghosh P. K., Celma M. L., Weissman S. M. The genome of simian virus 40. Science. 1978 May 5;200(4341):494–502. doi: 10.1126/science.205947. [DOI] [PubMed] [Google Scholar]
  25. Shah K., Nathanson N. Human exposure to SV40: review and comment. Am J Epidemiol. 1976 Jan;103(1):1–12. doi: 10.1093/oxfordjournals.aje.a112197. [DOI] [PubMed] [Google Scholar]
  26. Shin S. I., Freedman V. H., Risser R., Pollack R. Tumorigenicity of virus-transformed cells in nude mice is correlated specifically with anchorage independent growth in vitro. Proc Natl Acad Sci U S A. 1975 Nov;72(11):4435–4439. doi: 10.1073/pnas.72.11.4435. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Sleigh M. J., Topp W. C., Hanich R., Sambrook J. F. Mutants of SV40 with an altered small t protein are reduced in their ability to transform cells. Cell. 1978 May;14(1):79–88. doi: 10.1016/0092-8674(78)90303-3. [DOI] [PubMed] [Google Scholar]
  28. Takemoto K. K., Ting R. C., Ozer H. L., Fabisch P. Establishment of a cell line from an inbred mouse strain for viral transformation studies: simian virus 40 transformation and tumor production. J Natl Cancer Inst. 1968 Dec;41(6):1401–1409. [PubMed] [Google Scholar]
  29. Tegtmeyer P. Function of simian virus 40 gene A in transforming infection. J Virol. 1975 Mar;15(3):613–618. doi: 10.1128/jvi.15.3.613-618.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Tegtmeyer P., Schwartz M., Collins J. K., Rundell K. Regulation of tumor antigen synthesis by simain virus 40 gene A. J Virol. 1975 Jul;16(1):168–178. doi: 10.1128/jvi.16.1.168-178.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Tevethia S. S., MacMillan V. L. Acquisition of malignant properties by SV40-transformed mouse cells: relationship to type-C viral antigen expression. Intervirology. 1974;3(4):269–276. doi: 10.1159/000149763. [DOI] [PubMed] [Google Scholar]
  32. Wise K. S., Cassell G. H., Action R. T. Selective association of murine T lymphoblastoid cell surface alloantigens with Mycoplasma hyorhinis. Proc Natl Acad Sci U S A. 1978 Sep;75(9):4479–4483. doi: 10.1073/pnas.75.9.4479. [DOI] [PMC free article] [PubMed] [Google Scholar]

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