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. 1980 May;77(5):2960–2963. doi: 10.1073/pnas.77.5.2960

Genetically dominant resistance in mice to 3-methylcholanthrene-induced lymphoma.

A Mayer, F Lilly, M L Duran-Reynals
PMCID: PMC349526  PMID: 6930679

Abstract

Mice of the RF/J strain are highly susceptible to induction of thymic lymphoma by skin painting with 3-methylcholanthrene (MCA), whereas mice of the 129/J and I/LnJ strains are resistant. Resistance was the dominant trait in F1 mice of crosses of RF with each resistant strain. Analysis of the lymphoma incidence in MCA-painted backcross populations indicated segregation of a single dominant gene for resistance in both crosses. None of these strains show inducibility of the aryl hydrocarbon hydroxylase enzyme system, a phenotype attributed to the dominant Ahb gene which is also known to influence susceptibility to MCA-induced lymphoma. The occurrence of the disease in these backcrosses was independent of the hosts' phenotype at either the H-2 or Fv-1 locus, both of which have shown an influence on susceptibility to murine leukemia virus-associated lymphoma in other experimental systems.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Chattopadhyay S. K., Rowe W. P., Teich N. M., Lowy D. R. Definitive evidence that the murine C-type virus inducing locus Akv-1 is viral genetic material. Proc Natl Acad Sci U S A. 1975 Mar;72(3):906–910. doi: 10.1073/pnas.72.3.906. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Duran-Reynals M. L., Cook C. Resistance to skin tumorigenesis by 3-methylcholanthrene in mice susceptible to leukemia. J Natl Cancer Inst. 1974 Mar;52(3):1001–1003. doi: 10.1093/jnci/52.3.1001. [DOI] [PubMed] [Google Scholar]
  3. Duran-Reynals M. L., Lilly F., Bosch A., Blank K. J. The genetic basis of susceptibility to leukemia induction in mice by 3-methylcholanthrene applied percutaneously. J Exp Med. 1978 Feb 1;147(2):459–469. doi: 10.1084/jem.147.2.459. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. GORER P. A., MIKULSKA Z. B. The antibody response to tumor inoculation; improved methods of antibody detection. Cancer Res. 1954 Oct;14(9):651–655. [PubMed] [Google Scholar]
  5. Hartley J. W., Wolford N. K., Old L. J., Rowe W. P. A new class of murine leukemia virus associated with development of spontaneous lymphomas. Proc Natl Acad Sci U S A. 1977 Feb;74(2):789–792. doi: 10.1073/pnas.74.2.789. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Kouri R. E., Ratrie H., Whitmire C. E. Evidence of a genetic relationship between susceptibility to 3-methyl-cholanthrene-induced subcutaneous tumors and inducibility of aryl hydrocarbon hydroxylase. J Natl Cancer Inst. 1973 Jul;51(1):197–200. doi: 10.1093/jnci/51.1.197. [DOI] [PubMed] [Google Scholar]
  7. LILLY F., BOYSE E. A., OLD L. J. GENETIC BASIS OF SUSCEPTIBILITY TO VIRAL LEUKAEMOGENESIS. Lancet. 1964 Dec 5;2(7371):1207–1209. doi: 10.1016/s0140-6736(64)91043-8. [DOI] [PubMed] [Google Scholar]
  8. Lilly F., Duran-Reynals M. L., Rowe W. P. Correlation of early murine leukemia virus titer and H-2 type with spontaneous leukemia in mice of the BALB/c times AKR cross: a genetic analysis. J Exp Med. 1975 Apr 1;141(4):882–889. [PMC free article] [PubMed] [Google Scholar]
  9. Lilly F. The inheritance of susceptibility to the Gross leukemia virus in mice. Genetics. 1966 Mar;53(3):529–539. doi: 10.1093/genetics/53.3.529. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Lilly F. The role of genetics in Gross virus leukemogenesis. Bibl Haematol. 1970;(36):213–220. doi: 10.1159/000391710. [DOI] [PubMed] [Google Scholar]
  11. Pincus T., Hartley J. W., Rowe W. P. A major genetic locus affecting resistance to infection with murine leukemia viruses. I. Tissue culture studies of naturally occurring viruses. J Exp Med. 1971 Jun 1;133(6):1219–1233. doi: 10.1084/jem.133.6.1219. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Rowe W. P., Pincus T. Quantitative studies of naturally occurring murine leukemia virus infection of AKR mice. J Exp Med. 1972 Feb 1;135(2):429–436. doi: 10.1084/jem.135.2.429. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Rowe W. P., Sato H. Genetic mapping of the Fv-1 lcous of the mouse. Science. 1973 May 11;180(4086):640–641. doi: 10.1126/science.180.4086.640. [DOI] [PubMed] [Google Scholar]
  14. Rowe W. P. Studies of genetic transmission of murine leukemia virus by AKR mice. I. Crosses with Fv-1 n strains of mice. J Exp Med. 1972 Nov 1;136(5):1272–1285. doi: 10.1084/jem.136.5.1272. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Ruddle F. H., Shows T. B., Roderick T. H. Autosomal control of an electrophoretic variant of glucose-6-phosphate dehydrogenase in the mouse (Mus musculus). Genetics. 1968 Apr;58(4):599–606. doi: 10.1093/genetics/58.4.599. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Tennant J. R., Snell G. D. The H-2 locus and viral leukemogenesis as studied in congenic strains of mice. J Natl Cancer Inst. 1968 Aug;41(2):597–604. [PubMed] [Google Scholar]
  17. Thomas P. E., Kouri R. E., Hutton J. J. The genetics of aryl hydrocarbon hydroxylase induction in mice: a single gene difference between C57BL-6J and DBA-2J. Biochem Genet. 1972 Apr;6(2):157–168. doi: 10.1007/BF00486400. [DOI] [PubMed] [Google Scholar]

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