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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Autoimmunity. 2012 Jun 25;45(6):440–448. doi: 10.3109/08916934.2012.682668

Figure 3.

Figure 3

AID deficiency correlated with a decrease in interstitial T cell infiltration in the kidneys. (A) AID deficiency correlated with a reduction in infiltration of inflammatory cells in the renal interstitium. Each dot represents data from one mouse. JHT.mIg.MRL/lpr mice (N= 11) and JHT.mIg.AID−/−MRL/lpr mice (N = 12) at 5~6 months of age were used. The H&E stain of kidney sections were from representative JHT.mIg.MRL/lpr and AID-deficient counterparts. B. The majority of Infiltrated cells in the renal interstitium were T cells, with some B cells and a few macrophages. The stain of H&E, CD3, PAX5, and F4/80 in kidney sections were from a representative JHT.mIg.MRL/lpr mouse from the same study in (A). Mann-Whitney Rank Sum Test was performed.