Skip to main content
NCBI home page
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1980 Jun;77(6):3563–3566. doi: 10.1073/pnas.77.6.3563

Silent delta-globin gene in Old World monkeys.

S L Martin, E A Zimmer, Y W Kan, A C Wilson
PMCID: PMC349657  PMID: 6251467

Abstract

The delta polypeptide chain is present in the adult hemoglobin of all higher primates except Old World monkeys. Because Old World monkeys have evolved from higher primate ancestors, it can be concluded that the ability to synthesize this polypeptide has been lost relatively recently. It is shown here that the gene for delta globin exists in two of these species, the rhesus monkey (Macaca mulatta) and the baboon (Papio papio). Restriction endonuclease fragments of monkey genomic DNA bearing the delta- and beta-globin genes were detected after hybridization of human globin cDNA probes to filter-bound primate DNAs according to the Southern method. A restriction map prepared for rhesus DNA was identical in overall organization to the map of the human region. This indicates that large deletions or additions of DNA are not responsible for the Old World monkeys' lack of delta globin.

Full text

PDF
3563

Images in this article

3564Image
on p.3564

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Benveniste R. E., Todaro G. J. Evolution of type C viral genes: evidence for an Asian origin of man. Nature. 1976 May 13;261(5556):101–108. doi: 10.1038/261101a0. [DOI] [PubMed] [Google Scholar]
  2. Boyer S. H., Crosby E. F., Noyes A. N., Fuller G. F., Leslie S. E., Donaldson L. J., Vrablik G. R., Schaefer E. W., Jr, Thurmon T. F. Primate hemoglobins: Some sequences and some proposals concerning the character of evolution and mutation. Biochem Genet. 1971 Oct;5(5):405–448. doi: 10.1007/BF00487132. [DOI] [PubMed] [Google Scholar]
  3. Boyer S. H., Crosby E. F., Thurmon T. F., Noyes A. N., Fuller G. F., Leslie S. E., Shepard M. K., Herndon C. N. Hemoglobins A and A2 in New World primates: comparative variation and its evolutionary implications. Science. 1969 Dec 12;166(3911):1428–1431. doi: 10.1126/science.166.3911.1428. [DOI] [PubMed] [Google Scholar]
  4. Fritsch E. F., Lawn R. M., Maniatis T. Characterisation of deletions which affect the expression of fetal globin genes in man. Nature. 1979 Jun 14;279(5714):598–603. doi: 10.1038/279598a0. [DOI] [PubMed] [Google Scholar]
  5. Kan Y. W., Dozy A. M. Polymorphism of DNA sequence adjacent to human beta-globin structural gene: relationship to sickle mutation. Proc Natl Acad Sci U S A. 1978 Nov;75(11):5631–5635. doi: 10.1073/pnas.75.11.5631. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Lawn R. M., Fritsch E. F., Parker R. C., Blake G., Maniatis T. The isolation and characterization of linked delta- and beta-globin genes from a cloned library of human DNA. Cell. 1978 Dec;15(4):1157–1174. doi: 10.1016/0092-8674(78)90043-0. [DOI] [PubMed] [Google Scholar]
  7. Maniatis T., Jeffrey A., Kleid D. G. Nucleotide sequence of the rightward operator of phage lambda. Proc Natl Acad Sci U S A. 1975 Mar;72(3):1184–1188. doi: 10.1073/pnas.72.3.1184. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Nagel R. L., Bookchin R. M., Johnson J., Labie D., Wajcman H., Isaac-Sodeye W. A., Honig G. R., Schilirò G., Crookston J. H., Matsutomo K. Structural bases of the inhibitory effects of hemoglobin F and hemoglobin A2 on the polymerization of hemoglobin S. Proc Natl Acad Sci U S A. 1979 Feb;76(2):670–672. doi: 10.1073/pnas.76.2.670. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Orkin S. H. The duplicated human alpha globin genes lie close together in cellular DNA. Proc Natl Acad Sci U S A. 1978 Dec;75(12):5950–5954. doi: 10.1073/pnas.75.12.5950. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Proudfoot N. J., Baralle F. E. Molecular cloning of human epsilon-globin gene. Proc Natl Acad Sci U S A. 1979 Nov;76(11):5435–5439. doi: 10.1073/pnas.76.11.5435. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Weatherall D. J., Clegg J. B. Recent developments in the molecular genetics of human hemoglobin. Cell. 1979 Mar;16(3):467–479. doi: 10.1016/0092-8674(79)90022-9. [DOI] [PubMed] [Google Scholar]
  12. Weaver S., Haigwood N. L., Hutchison C. A., 3rd, Edgell M. H. DNA fragments of the Mus musculus beta globin haplotypes Hbbs and Hbbd. Proc Natl Acad Sci U S A. 1979 Mar;76(3):1385–1389. doi: 10.1073/pnas.76.3.1385. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Wilson A. C., Carlson S. S., White T. J. Biochemical evolution. Annu Rev Biochem. 1977;46:573–639. doi: 10.1146/annurev.bi.46.070177.003041. [DOI] [PubMed] [Google Scholar]
  14. Wilson J. T., Wilson L. B., deRiel J. K., Villa-komaroff L., Efstratiadis A., Forget B. G., Weissman S. M. Insertion of synthetic copies of human globin genes into bacterial plasmids. Nucleic Acids Res. 1978 Feb;5(2):563–581. doi: 10.1093/nar/5.2.563. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Zimmer E. A., Martin S. L., Beverley S. M., Kan Y. W., Wilson A. C. Rapid duplication and loss of genes coding for the alpha chains of hemoglobin. Proc Natl Acad Sci U S A. 1980 Apr;77(4):2158–2162. doi: 10.1073/pnas.77.4.2158. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES