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. 1980 Jun;77(6):3586–3589. doi: 10.1073/pnas.77.6.3586

Gene deletions in alpha thalassemia prove that the 5' zeta locus is functional.

L Pressley, D R Higgs, J B Clegg, D J Weatherall
PMCID: PMC349662  PMID: 6158051

Abstract

The deletions in the zeta-alpha globin gene cluster in two infants with the hemoglobin Bart's hydrops fetalis syndrome (homozygous alpha thalassemia 1) have been mapped by restriction endonuclease analysis using a zeta-specific probe. DNA from a Thai infant lacked the psi alpha 1 gene and both alpha genes, but the zeta genes were present. A Greek infant's DNA had also lost the 3' zeta 1 gene. Because zeta globin was synthesized in the infant's cord blood, this indicates that the 5' zeta 2 gene recently identified by Lauer et al. [Lauer, J., Shen, C. J. & Maniatis, T. (1980) Cell, in press] must be functional.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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