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. 1980 Jul;77(7):4084–4088. doi: 10.1073/pnas.77.7.4084

Platelet-derived growth factor stimulates activity of low density lipoprotein receptors.

A Chait, R Ross, J J Albers, E L Bierman
PMCID: PMC349774  PMID: 6933457

Abstract

Partially purified platelet-derived growth factor stimulates low density lipoprotein binding and degradation in cultured aortic smooth muscle cells of monkeys by increasing the number of available low density lipoprotein receptors. When platelet-derived growth factor was added to quiescent cells, low density lipoprotein binding increased within 4-8 hr. Stimulation of low density lipoprotein receptor activity preceded stimulation of DNA synthesis by platelet-derived growth factor by 8-12 hr. Enhancement of endogenous cholesterol synthesis by platelet-derived growth factor preceded stimulation of low density lipoprotein receptor activity. These findings suggest that the platelet-derived growth factor can increase both the exogenous and endogenous supplies of cholesterol to the cell for its use during cell proliferation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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