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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1980 Jul;77(7):4247–4250. doi: 10.1073/pnas.77.7.4247

HLA antigen-related restriction of T lymphocyte cytotoxicity to Epstein-Barr virus.

I S Misko, D J Moss, J H Pope
PMCID: PMC349809  PMID: 6254017

Abstract

The specificity of cytotoxic T cells generated in Epstein-Barr virus (EBV)-infected lymphocyte cultures was investigated, using a 51Cr release assay. Potent cytotoxic T cells with preferred specificity directed to antigens expressed on autologous lymphoblastoid cell line (LCL) target cells were present in 14-day cultures of lymphocytes from EBV-seropositive donors and not from seronegative donors. Moreover, the cytotoxic patterns obtained with a panel of HLA antigen-related and unrelated LCL target cells, supported by unlabeled target inhibition tests, strongly indicate that T cell cytotoxicity to EBV is restricted to HLA antigens.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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