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. 1980 Aug;77(8):4607–4609. doi: 10.1073/pnas.77.8.4607

Induction of ornithine decarboxylase by renin-free nerve growth factor.

G Guroff, P Montgomery, N Tolson, M E Lewis, D End
PMCID: PMC349893  PMID: 7001462

Abstract

Renin-free nerve growth factor causes the induction of ornithine decarboxylase (L-ornithine carboxy-lyase, EC 4.1.1.17) in superior cervical ganglia from neonatal rats but not in the brain of mature rats. Less pure preparations of nerve growth factor induce the enzyme in both brain and ganglia. The induction of ornithine decarboxylase in the central nervous system appears to be due to renin, not to nerve growth factor itself.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Angeletti P., Vigneti E. Assay of nerve growth factor (NGF) in subcellular fractions of peripheral tissues by micro complement fixation. Brain Res. 1971 Oct 29;33(2):601–604. doi: 10.1016/0006-8993(71)90148-x. [DOI] [PubMed] [Google Scholar]
  2. Avrith D. B., Lewis M. E., Fitzsimons J. T. Renin-like effects of NGF evaluated using renin-angiotensin antagonists. Nature. 1980 May 22;285(5762):248–250. doi: 10.1038/285248a0. [DOI] [PubMed] [Google Scholar]
  3. Benowitz L. I., Greene L. A. Nerve growth factor in the goldfish brain: biological assay studies using pheochromocytoma cells. Brain Res. 1979 Feb 16;162(1):164–168. doi: 10.1016/0006-8993(79)90767-4. [DOI] [PubMed] [Google Scholar]
  4. Benowitz L. I., Shashoua V. E. Immunoreactive sites for nerve growth factor (NGF) in the goldfish brain. Brain Res. 1979 Aug 31;172(3):561–565. doi: 10.1016/0006-8993(79)90589-4. [DOI] [PubMed] [Google Scholar]
  5. Berger B. D., Wise C. D., Stein L. Nerve growth factor: enhanced recovery of feeding after hypothalamic damage. Science. 1973 May 4;180(4085):506–508. doi: 10.1126/science.180.4085.506. [DOI] [PubMed] [Google Scholar]
  6. Bjerre B., Björklund A., Stenevi U. Stimulation of growth of new axonal sprouts from lesioned monoamine neurones in adult rat brain by nerve growth factor. Brain Res. 1973 Sep 28;60(1):161–176. doi: 10.1016/0006-8993(73)90855-x. [DOI] [PubMed] [Google Scholar]
  7. Björklund A., Stenevi U. Nerve growth factor: stimulation of regenerative growth of central noradrenergic neurons. Science. 1972 Mar 17;175(4027):1251–1253. doi: 10.1126/science.175.4027.1251. [DOI] [PubMed] [Google Scholar]
  8. Bocchini V., Angeletti P. U. The nerve growth factor: purification as a 30,000-molecular-weight protein. Proc Natl Acad Sci U S A. 1969 Oct;64(2):787–794. doi: 10.1073/pnas.64.2.787. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Cozzari C., Angeletti P. U., Lazar J., Orth H., Gross F. Separation of isorenin activity from nerve growth factor (NGF) activity in mouse submaxillary gland extracts. Biochem Pharmacol. 1973 Jun 1;22(11):1321–1327. doi: 10.1016/0006-2952(73)90306-7. [DOI] [PubMed] [Google Scholar]
  10. Cushman D. W., Cheung H. S., Sabo E. F., Rubin B., Ondetti M. A. Development of specific inhibitors of angiotensin I converting enzyme (kininase II). Fed Proc. 1979 Dec;38(13):2778–2782. [PubMed] [Google Scholar]
  11. Frazier W. A., Boyd L. F., Pulliam M. W., Szutowicz A., Bradshaw R. A. Properties and specificity of binding sites for 125I-nerve growth factor in embryonic heart and brain. J Biol Chem. 1974 Sep 25;249(18):5918–5923. [PubMed] [Google Scholar]
  12. Frazier W. A., Boyd L. F., Szutowicz A., Pulliam M. W., Bradshaw R. A. Specific binding sites for 125I-nerve growth factor in peripheral tissues and brain. Biochem Biophys Res Commun. 1974 Apr 23;57(4):1096–1103. doi: 10.1016/0006-291x(74)90809-2. [DOI] [PubMed] [Google Scholar]
  13. Green L. A. A quantitative bioassay for nerve growth factor (NGF) activity employing a clonal pheochromocytoma cell line. Brain Res. 1977 Sep 16;133(2):350–353. doi: 10.1016/0006-8993(77)90770-3. [DOI] [PubMed] [Google Scholar]
  14. Greene L. A., McGuire J. C. Induction of ornithine decarboxylase by nerve growth factor dissociated from effects on survival and neurite outgrowth. Nature. 1978 Nov 9;276(5684):191–194. doi: 10.1038/276191a0. [DOI] [PubMed] [Google Scholar]
  15. Hatanaka H., Otten U., Thoenen H. Nerve growth factor-mediated selective induction of ornithine decarboxylase in rat pheochromocytoma; a cyclic AMP-independent process. FEBS Lett. 1978 Aug 15;92(2):313–316. doi: 10.1016/0014-5793(78)80777-7. [DOI] [PubMed] [Google Scholar]
  16. Hendry I. A. Developmental changes in tissue and plasma concentrations of the biologically active species of nerve growth factor in the mouse, by using a two-site radioimmunoassay. Biochem J. 1972 Aug;128(5):1265–1272. doi: 10.1042/bj1281265. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Huff K. R., Guroff G. Nerve growth factor-induced reduction in epidermal growth factor responsiveness and epidermal growth factor receptors in PC12 cells: an aspect of cell differentiation. Biochem Biophys Res Commun. 1979 Jul 12;89(1):175–180. doi: 10.1016/0006-291x(79)90960-4. [DOI] [PubMed] [Google Scholar]
  18. Johnson D. G., Gorden P., Kopin I. J. A sensitive radioimmunoassay for 7S nerve growth factor antigens in serum and tissues. J Neurochem. 1971 Dec;18(12):2355–2362. doi: 10.1111/j.1471-4159.1971.tb00190.x. [DOI] [PubMed] [Google Scholar]
  19. Levi-Montalcini R. Polydipsia after intracranial injections--a property of NGF or a contaminant? Nature. 1980 Apr 10;284(5756):577–577. doi: 10.1038/284577a0. [DOI] [PubMed] [Google Scholar]
  20. Lewis M. E., Avrith D. B., Fitzsimons J. T. Short-latency drinking and increased Na appetite after intracerebral microinjections of NGF in rats. Nature. 1979 May 31;279(5712):440–442. doi: 10.1038/279440a0. [DOI] [PubMed] [Google Scholar]
  21. Lewis M. E., Lakshmanan J., Nagaiah K., Macdonnell P. C., Guroff G. Nerve growth factor increases activity of ornithine decarboxylase in rat brain. Proc Natl Acad Sci U S A. 1978 Feb;75(2):1021–1023. doi: 10.1073/pnas.75.2.1021. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. MacDonnell P. C., Nagaiah K., Lakshmanan J., Guroff G. Nerve growth factor increases activity of ornithine decarboxylase in superior cervical ganglia of young rats. Proc Natl Acad Sci U S A. 1977 Oct;74(10):4681–4684. doi: 10.1073/pnas.74.10.4681. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. McCaa R. E. Studies in vivo with angiotensin I converting enzyme (kininase II) inhibitors. Fed Proc. 1979 Dec;38(13):2783–2787. [PubMed] [Google Scholar]
  24. Nagaiah K., Ikeno T., Lakshmanan J., MacDonnell P., Guroff G. Intraventricular administration of nerve growth factor induces ornithine decarboxylase in peripheral tissues of the rat. Proc Natl Acad Sci U S A. 1978 May;75(5):2512–2515. doi: 10.1073/pnas.75.5.2512. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Oka T., Perry J. W. Studies on regulatory factors of ornithine decarboxylase activity during development of mouse mammary epithelium in vitro. J Biol Chem. 1976 Mar 25;251(6):1738–1744. [PubMed] [Google Scholar]
  26. Otten U., Baumann J. B., Girard J. Stimulation of the pituitary-adrenocortical axis by nerve growth factor. Nature. 1979 Nov 22;282(5737):413–414. doi: 10.1038/282413a0. [DOI] [PubMed] [Google Scholar]
  27. Perkins M. S., Margules D. L., Ward I. L. Nerve growth factor: intense polydipsia of long duration produced by ventral diencephalic application. Brain Res. 1979 Feb 2;161(2):351–355. doi: 10.1016/0006-8993(79)90077-5. [DOI] [PubMed] [Google Scholar]
  28. Szutowicz A., Frazier W. A., Bradshaw R. A. Subcellular localization of nerve growth factor receptors. Developmental correlations in chick embryo brain. J Biol Chem. 1976 Mar 10;251(5):1524–1528. [PubMed] [Google Scholar]
  29. Szutowicz A., Frazier W. A., Bradshaw R. A. Subcellular localization of nerve growth factor receptors. Thirteen-day chick embryo brain. J Biol Chem. 1976 Mar 10;251(5):1516–1523. [PubMed] [Google Scholar]
  30. Walker P., Weichsel M. E., Jr, Fisher D. A., Guo S. M., Fisher D. A. Thyroxine increases nerve growth factor concentration in adult mouse brain. Science. 1979 Apr 27;204(4391):427–429. doi: 10.1126/science.441732. [DOI] [PubMed] [Google Scholar]
  31. Yu M. W., Hori S., Tolson N., Huff K., Guroff G. Increased phosphorylation of a specific nuclear protein in rat superior cervical ganglia in response to nerve growth factor. Biochem Biophys Res Commun. 1978 Apr 14;81(3):941–946. doi: 10.1016/0006-291x(78)91442-0. [DOI] [PubMed] [Google Scholar]

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