Skip to main content
. 2012 Jul 1;4(4):445–457. doi: 10.4161/mabs.20776

Table 1. mAb properties and functions that can be modified by molecular engineering. “Diagnostic purposes” includes both in vitro diagnosis (EIA) and in vivo imaging.

Optimization of mAb properties and functions.
Type of modification Therapeutic purposes Diagnostic purposes:
in vitro diagnosis and in vivo imaging
Immunogenicity.
Yes
No
Binding properties:
affinity or specificity for antigen
Yes
Yes
Binding properties:
affinity or specificity for FcγR.
Yes
No
Effector functions:
ADCC, ADCP, CDC.
Yes
No
Biophysical characteristics:
solubility, chemical stability.
Yes
Yes
Pharmacokinetics:
serum half-life.
Yes
Yes (imaging)
Biochemical properties:
glycosylation, isoelectric point.
Yes
Yes
Labeling. No Yes