Table 1. mAb properties and functions that can be modified by molecular engineering. “Diagnostic purposes” includes both in vitro diagnosis (EIA) and in vivo imaging.
| Optimization of mAb properties and functions. | ||
|---|---|---|
| Type of modification | Therapeutic purposes | Diagnostic purposes: in vitro diagnosis and in vivo imaging |
|
Immunogenicity. |
Yes |
No |
|
Binding properties: affinity or specificity for antigen |
Yes |
Yes |
|
Binding properties: affinity or specificity for FcγR. |
Yes |
No |
|
Effector functions: ADCC, ADCP, CDC. |
Yes |
No |
|
Biophysical characteristics: solubility, chemical stability. |
Yes |
Yes |
|
Pharmacokinetics: serum half-life. |
Yes |
Yes (imaging) |
|
Biochemical properties: glycosylation, isoelectric point. |
Yes |
Yes |
| Labeling. | No | Yes |