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. 1980 Sep;77(9):5437–5440. doi: 10.1073/pnas.77.9.5437

Establishment of the interferon-mediated antiviral state: role of fatty acid cyclooxygenase.

R Pottathil, K A Chandrabose, P Cuatrecasas, D J Lang
PMCID: PMC350074  PMID: 6159647

Abstract

Inhibitors of fatty acid cyclooxygenase 8,11,14-icosatrienoate, hydrogen donor:oxygen oxidoreductase, EC 1.14.99.1) were found to suppress the establishment of the interferon-mediated antiviral state. The prevention, by these compounds, of the development of interferon protection correlated with the degree as well as the duration of cyclooxygenase inhibition. Anti-inflammatory substances lacking cyclooxygenase inhibitory activity did not interfere with the establishment of interferon protection. The addition of exogenous prostaglandins was not found to replace the need for a functional cyclooxygenase and, in some instances, could be shown to diminish the establishment of interferon protection. It is proposed that fatty acid cyclooxygenase is an essential component in the optimal induction of the interferon antiviral state.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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