Skip to main content
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1980 Sep;77(9):5480–5482. doi: 10.1073/pnas.77.9.5480

Albumin Naskapi variant in North American Indians and Eti Turks.

S G Franklin, S I Wolf, Y Ozdemir, G T Yüregir, T Isbir, B S Blumberg
PMCID: PMC350084  PMID: 6933567

Abstract

Both conventional polyacrylamide gel electrophoresis and a new type of electrophoretic screening procedure indicate that the polymorphic albumin variants Naskapi, found chiefly in the Naskapi Indians of Quebec, and Mersin, found in the Eti Turks of southeastern Turkey, are molecularly identical or very similar and that the amino acid substitution site in these variants is located between residues 330 and 446. This discovery is consistent with a genetic relationship between the Eti Turks and American Indians. We also report a new variant found in the Eti Turks, albumin Adana, which migrates similarly to albumin B on conventional gels but which our new system shows to differ from the common albumin A and albumin B by a substitution between residues 549 and 585.

Full text

PDF
5480

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Franklin S. G., Wolf S. I., Zweidler A., Blumberg B. S. Localization of the amino acid substitution site in a new variant of human serum albumin, albumin Mexico-2. Proc Natl Acad Sci U S A. 1980 May;77(5):2505–2509. doi: 10.1073/pnas.77.5.2505. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Franklin S. G., Zweidler A. Non-allelic variants of histones 2a, 2b and 3 in mammals. Nature. 1977 Mar 17;266(5599):273–275. doi: 10.1038/266273a0. [DOI] [PubMed] [Google Scholar]
  3. Johnston F. E., Blumberg B. S., Agarwal S. S., Melartin L., Burch T. A. Alloalbuminemia in southwestern U.S. indians: polymorphism of albumin Naskapi and albumin Mexico. Hum Biol. 1969 May;41(2):263–270. [PubMed] [Google Scholar]
  4. Urban M. K., Franklin S. G., Zweidler A. Isolation and characterization of the histone variants in chicken erythrocytes. Biochemistry. 1979 Sep 4;18(18):3952–3960. doi: 10.1021/bi00585a017. [DOI] [PubMed] [Google Scholar]
  5. Wilding G., Blumberg E. S., Vesell E. S. Reduced warfarin binding of albumin variants. Science. 1977 Mar 11;195(4282):991–994. doi: 10.1126/science.841323. [DOI] [PubMed] [Google Scholar]
  6. Winter W. P., Weitkamp L. R., Rucknagel D. L. Amino acid substitution in two identical inherited human serum albumin variants: albumin Oliphant and albumin Ann Arbor. Biochemistry. 1972 Feb 29;11(5):889–896. doi: 10.1021/bi00755a031. [DOI] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES