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. 1980 Sep;77(9):5525–5526. doi: 10.1073/pnas.77.9.5525

Peptide inhibitor of morphine- and beta-endorphin-induced analgesia.

N M Lee, H J Friedman, L Leybin, T M Cho, H H Loh, C H Li
PMCID: PMC350094  PMID: 6254086

Abstract

The synthetic beta-endorphin analogs with the omission of the NH2-terminal [Met]enkephalin segment [beta-endorphin-(6-31) and beta-endorphin-(20-31)] are shown to inhibit morphine- or beta-endorphin-induced analgesia in mice by the tail-flick test, whereas the synthetic NH2-terminal pentadecapeptide beta-endorphin-(1-15) has no inhibitory activity. This study raises the possibility that endogenous inhibiting peptides exist in the brain which play a role in the regulation of endorphin actions.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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