Abstract
The principles that underlie enzyme catalysis also apply to energy coupling processes. A comparison is made between a kinase system that mediates the phosphorylation of glucose by ATP (hexokinase), as the prototype for enzymic catalysis, and the mitochondrial electron-transfer complexes, as the prototypes for energy coupling systems. Induced polarization of chemical bonds and charge separation and elimination are common component events of both enzyme catalysis and energy coupling. Thus, definite limits can be imposed on models of energy coupling; they must comply with the basic principles of enzymic catalysis.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Chipman D. M., Sharon N. Mechanism of lysozyme action. Science. 1969 Aug 1;165(3892):454–465. doi: 10.1126/science.165.3892.454. [DOI] [PubMed] [Google Scholar]
- Gurd F. R., Rothgeb T. M. Motions in proteins. Adv Protein Chem. 1979;33:73–165. doi: 10.1016/s0065-3233(08)60459-3. [DOI] [PubMed] [Google Scholar]
- Janin J., Chothia C. Stability and specificity of protein-protein interactions: the case of the trypsin-trypsin inhibitor complexes. J Mol Biol. 1976 Jan 15;100(2):197–211. doi: 10.1016/s0022-2836(76)80148-9. [DOI] [PubMed] [Google Scholar]
- Lee B., Richards F. M. The interpretation of protein structures: estimation of static accessibility. J Mol Biol. 1971 Feb 14;55(3):379–400. doi: 10.1016/0022-2836(71)90324-x. [DOI] [PubMed] [Google Scholar]
- Lipscomb W. N. Enzymatic activities of carobxypeptidase A's in solution and in crystals. Proc Natl Acad Sci U S A. 1973 Dec;70(12):3797–3801. doi: 10.1073/pnas.70.12.3797. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Matthews R. G., Ballou D. P., Thorpe C., Williams C. H., Jr Ion pair formation in pig heart lipoamide dehydrogenase: rationalization of pH profiles for reactivity of oxidized enzyme with dihydrolipoamide and 2-electron-reduced enzyme with lipoamide and iodoacetamide. J Biol Chem. 1977 May 25;252(10):3199–3207. [PubMed] [Google Scholar]
- Stubbe J., Fish S., Abeles R. H. Are carboxylations involving biotin concerted or nonconcerted? J Biol Chem. 1980 Jan 10;255(1):236–242. [PubMed] [Google Scholar]