Table 2. Overview of approaches to enforce correct heavy chain association in the heavy chain CH3 domains of heavy chain 1 (HC1) and heavy chain 2 (HC2).

HC1	HC2	Type	Reference
Y349C, T366S, L368A, Y407V	S354C, T366W	KiH + S-S stabilization SAV-W	25
E356K, E357K, D399K	K370E, K409D, K439E	Ionic, electrostatic	33
K392D, K409D	E356K, D399K	Ionic, electrostatic DD-KK	34
S364H, F405A	Y349T, T394F	Mixed HA-TF	35
Fusion of leucine zipper A to C-terminus of CH3	Fusion of leucine zipper A to C-terminus of CH3	LUZ-Y	40
IgG CH3	IgA CH3	SEEDbody	36