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. 1980 Dec;77(12):7377–7379. doi: 10.1073/pnas.77.12.7377

Cell cycle-specific mutagenesis at the hypoxanthine phosphoribosyltransferase locus in adult rat liver epithelial cells.

C Tong, M Fazio, G M Williams
PMCID: PMC350506  PMID: 6938982

Abstract

The cell cycle specificity of chemical mutagenesis was studied by use of two cell synchronization techniques, one a nontoxic technique involving serum deprivation and the other a double thymidine block, to obtain rat liver epithelial cells in different phases of the cell cycle to be exposed to chemical mutagens. For both methyl methanesulfonate and N-methyl-N'-nitro-N-nitrosoguanidine, there was a cell cycle specificity of chemical mutagenesis, with the most sensitive phase being the period of DNA synthesis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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