Abstract
Cell-mediated immune response and humoral response to chlamydial antigens were investigated in guinea pigs infected with the agent of guinea pig inclusion conjunctivitis (GPIC). Pronounced cell-mediated immune response to the homologous antigen, as well as to two other chlamydial antigens, 6BC (Chlamydia psittaci) and LB-1 (C. trachomatis), occurred in all infected animals. Cell-mediated immune response to GPIC, and to a lesser extent to 6BC and LB-1 as well, was enhanced with time after infection even without the re-inoculation of the infectious agent. Extensive cross-reactions among the three chlamydial antigens during the cell-mediated immune response appeared to be due to shared species-specific and group-reactive antigens. Serum antibody response was pronounced and uniform to GPIC; it was less marked to 6BC and LB-1, with fewer cross-reactions than seen in tests for cell-mediated immunity.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Briones O. C., Hanna L., Jawetz E., Dawson C. R., Ostler H. B. Type-specific antibodies in human Chlamydia trachomatis infections of the eye. J Immunol. 1974 Oct;113(4):1262–1270. [PubMed] [Google Scholar]
- DAVID J. R., AL-ASKARI S., LAWRENCE H. S., THOMAS L. DELAYED HYPERSENSITIVITY IN VITRO. I. THE SPECIFICITY OF INHIBITION OF CELL MIGRATION BY ANTIGENS. J Immunol. 1964 Aug;93:264–273. [PubMed] [Google Scholar]
- Hanna L., Jawetz E., Nabli B., Hoshiwara I., Ostler B., Dawson C. Titration and typing of serum antibodies in TRIC infections by immunofluorescence. J Immunol. 1972 Jan;108(1):102–107. [PubMed] [Google Scholar]
- Hanna L., Schmidt L., Sharp M., Stites D. P., Jawetz E. Human cell-mediated immune responses to chlamydial antigens. Infect Immun. 1979 Feb;23(2):412–417. doi: 10.1128/iai.23.2.412-417.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kazdan J. J., Schachter J., Okumoto M. Inclusion conjunctivitis in the guinea pig. Am J Ophthalmol. 1967 Jul;64(1):116–124. doi: 10.1016/0002-9394(67)93351-x. [DOI] [PubMed] [Google Scholar]
- MURRAY E. S. GUINEA PIG INCLUSION CONJUNCTIVITIS VIRUS. I. ISOLATION AND IDENTIFICATION AS A MEMBER OF THE PSITTACOSIS-LYMPHOGRANULOMA-TRACHOMA GROUP. J Infect Dis. 1964 Feb;114:1–12. doi: 10.1093/infdis/114.1.1. [DOI] [PubMed] [Google Scholar]
- Modabber F., Bear S. E., Cerny J. The effect of cyclophosphamide on the recovery from a local chlamydial infection. Guinea-pig inclusion conjunctivitis (GPIC). Immunology. 1976 Jun;30(6):929–933. [PMC free article] [PubMed] [Google Scholar]
- Mount D. T., Bigazzi P. E., Barron A. L. Experimental genital infection of male guinea pigs with the agent of guinea pig inclusion conjunctivitis and transmission to females. Infect Immun. 1973 Dec;8(6):925–930. doi: 10.1128/iai.8.6.925-930.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
- REEVE P., TAVERNE J. A simple method for total particle counts of trachoma and inclusion blennorrhoea viruses. Nature. 1962 Sep 1;195:923–924. doi: 10.1038/195923a0. [DOI] [PubMed] [Google Scholar]
- Schachter J. Chlamydial infections (third of three parts). N Engl J Med. 1978 Mar 9;298(10):540–549. doi: 10.1056/NEJM197803092981005. [DOI] [PubMed] [Google Scholar]
- Senyk G., Sharp M., Stites D. P., Hanna L., Keshishyan H., Jawetz E. Cell-mediated immune responses to chlamydial antigens in guinea pigs injected with inactivated chlamydiae. Med Microbiol Immunol. 1980;168(2):91–101. doi: 10.1007/BF02121757. [DOI] [PubMed] [Google Scholar]
- Watson R. R., MacDonald A. B., Murray E. S., Modabber F. Z. Immunity to chlamydial infections of the eye. 3. Presence and duration of delayed hypersensitivity to guinea pig inclusion conjuctivitis. J Immunol. 1973 Aug;111(2):618–623. [PubMed] [Google Scholar]