Skip to main content
. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: Gene. 2012 Aug 20;509(1):16–23. doi: 10.1016/j.gene.2012.08.016

Figure 1. Evolutionary Conserved Pitx2 Binding Sites.

Figure 1

Comparative analysis of Pitx2 consensus sequence binding sites in Pitx2 target genes. The gene and the −20kb region upstream of the transcriptional start site were mapped against the aligned sequences in the top 15 Pitx2 target genes. Columns of red dots indicate a predicted Pitx2 binding site and the number of species the motif was conserved in, for all sites with conservation in at least 4 species. Binding sites with 3 or less conserved species not shown for clarity. Black boxes outline the binding sites that were found to be conserved in all 8 of the species.