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. 1981 Jul;33(1):297–303. doi: 10.1128/iai.33.1.297-303.1981

Effect of host age on experimental K virus infection in mice.

J E Greenlee
PMCID: PMC350689  PMID: 7263066

Abstract

Mice were inoculated by the oral route with K virus at 4, 8, 12, and 23 days and at 4 months of age. The effect of host age on the pathogenesis of infection was studied by immunofluorescence, virus assay, and histopathology. K virus produced a systemic infection in all animals, although the infection because progressively more limited as animals matured. In mice inoculated at 4 days of age, K virus infection resulted in a fatal interstitial pneumonia identical to that seen in newborn animals and was characterized by the presence of virus and viral antigen in pulmonary and extrapulmonary vascular endothelia, reticuloendothelial organs, and brains. In older animals, K virus infection was clinically inapparent; organ involvement was similar in distribution to that seen in fatally infected suckling ice, but cells exhibiting specific viral fluorescence were fewer in number and viral titers were lower. Although animals surviving K virus infection developed high titers of hemagglutination inhibition antibody to the virus, positive cells and infectious virus could still be detected in intestines 2 months after inoculation. In animals inoculated at 8 and 12 days of age, in which K virus produced an extensive initial infection, virus could also be detected 56 days after inoculation in lungs, livers, spleens, and brains. The present study indicates that murine K virus produces a systemic infection throughout the life of its host and that the maturation of host defenses and the development of specific humoral immunity, although they limit dissemination of virus during acute infection, may not eliminate viral persistence in intestines or other organs once infection has occurred.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ASHKENAZI A., MELNICK J. L. Induced latent infection of monkeys with vacuolating SV-40 Papova virus. Virus in kidneys and urine. Proc Soc Exp Biol Med. 1962 Nov;111:367–372. doi: 10.3181/00379727-111-27794. [DOI] [PubMed] [Google Scholar]
  2. DERRICK E. H., POPE J. H. Murine typhus, mice, rats and fleas on the Darling Downs. Med J Aust. 1960 Dec 10;47(2):924–928. doi: 10.5694/j.1326-5377.1960.tb23925.x. [DOI] [PubMed] [Google Scholar]
  3. FISHER E. R., KILHAM L. Pathology of a pneumotropic virus recovered from C3H mice carrying the Bittner milk agent. AMA Arch Pathol. 1953 Jan;55(1):14–19. [PubMed] [Google Scholar]
  4. Gleiser C. A., Heck F. C. The pathology of experimental K-virus infection in suckling mice. Lab Anim Sci. 1972 Dec;22(6):865–869. [PubMed] [Google Scholar]
  5. Greenlee J. E. Pathogenesis of K virus infection in newborn mice. Infect Immun. 1979 Nov;26(2):705–713. doi: 10.1128/iai.26.2.705-713.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Gribble D. H., Haden C. C., Schwartz L. W., Henrickson R. V. Spontaneous progressive multifocal leukoencephalopathy (PML) in macaques. Nature. 1975 Apr 17;254(5501):602–604. doi: 10.1038/254602a0. [DOI] [PubMed] [Google Scholar]
  7. HOLT D. Presence of K-virus in wild mice in Australia. Aust J Exp Biol Med Sci. 1959 Apr;37:183–191. doi: 10.1038/icb.1959.20. [DOI] [PubMed] [Google Scholar]
  8. Hirsch M. S., Zisman B., Allison A. C. Macrophages and age-dependent resistance to Herpes simplex virus in mice. J Immunol. 1970 May;104(5):1160–1165. [PubMed] [Google Scholar]
  9. Hogan T. F., Borden E. C., McBain J. A., Padgett B. L., Walker D. L. Human polyomavirus infections with JC virus and BK virus in renal transplant patients. Ann Intern Med. 1980 Mar;92(3):373–378. doi: 10.7326/0003-4819-92-3-373. [DOI] [PubMed] [Google Scholar]
  10. Holmberg C. A., Gribble D. H., Takemoto K. K., Howley P. M., Espana C., Osburn B. I. Isolation of simian virus 40 from rhesus monkeys (Macaca mulatta) with spontaneous progressive multifocal leukoencephalopathy. J Infect Dis. 1977 Oct;136(4):593–596. doi: 10.1093/infdis/136.4.593. [DOI] [PubMed] [Google Scholar]
  11. Jordan S. W., Doughty W. E. Ultrastructural pathology of murine pneumonitis caused by K-Papovavirus. Exp Mol Pathol. 1969 Aug;11(1):1–7. doi: 10.1016/0014-4800(69)90065-3. [DOI] [PubMed] [Google Scholar]
  12. KILHAM L. Hemagglutination by K-virus. Virology. 1961 Nov;15:384–385. doi: 10.1016/0042-6822(61)90372-5. [DOI] [PubMed] [Google Scholar]
  13. KILHAM L. Isolation in suckling mice of a virus from C3H mice harboring Bittner milk agent. Science. 1952 Oct 10;116(3015):391–392. doi: 10.1126/science.116.3015.391. [DOI] [PubMed] [Google Scholar]
  14. KILHAM L., MURPHY H. W. A pneumotropic virus isolated from C3H mice carrying the Bittner Milk Agent. Proc Soc Exp Biol Med. 1953 Jan;82(1):133–137. doi: 10.3181/00379727-82-20044. [DOI] [PubMed] [Google Scholar]
  15. Margolis G., Jacobs L. R., Kilham L. Oxygen tension and the selective tropism of K-virus for mouse pulmonary endothelium. Am Rev Respir Dis. 1976 Jul;114(1):45–51. doi: 10.1164/arrd.1976.114.1.45. [DOI] [PubMed] [Google Scholar]
  16. Mokhtarian F., Shah K. V. Role of antibody response in recovery from K-papovavirus infection in mice. Infect Immun. 1980 Sep;29(3):1169–1179. doi: 10.1128/iai.29.3.1169-1179.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Padgett B. L., Walker D. L., ZuRhein G. M., Eckroade R. J., Dessel B. H. Cultivation of papova-like virus from human brain with progressive multifocal leucoencephalopathy. Lancet. 1971 Jun 19;1(7712):1257–1260. doi: 10.1016/s0140-6736(71)91777-6. [DOI] [PubMed] [Google Scholar]

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