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. 1981 Aug;33(2):331–337. doi: 10.1128/iai.33.2.331-337.1981

Hypoglycemia in mice injected with interferon inducers is not mediated by interferon.

F Vignaux, I Gresser
PMCID: PMC350702  PMID: 6168587

Abstract

Injection of mice with several viral and nonviral inducers of interferon resulted in a marked hypoglycemia. Interferon is not responsible for this effect since inoculation of a potent antiserum to interferon (which neutralized the endogenous interferon) did not prevent hypoglycemia and administration of potent interferon preparations did not lower blood sugar. Hypoglycemia induced by Newcastle disease virus and polyriboinosinic-polyribocytidylic acid was further exacerbated by injection of insulin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Absher M., Stinebring W. R. Toxic properties of a synthetic double-stranded RNA. Endotoxin-like properties of poly I. poly C, an interferon stimulator. Nature. 1969 Aug 16;223(5207):715–717. doi: 10.1038/223715a0. [DOI] [PubMed] [Google Scholar]
  2. Adamson R. H., Fabro S. Embryotoxic effect of poly I. poly C. Nature. 1969 Aug 16;223(5207):718–718. doi: 10.1038/223718a0. [DOI] [PubMed] [Google Scholar]
  3. BERRY L. J., SMYTHE D. S., YOUNG L. G. Effects of bacterial endotoxin on metabolism. I. Carbohydrate depletion and the protective role of cortisone. J Exp Med. 1959 Sep 1;110:389–405. doi: 10.1084/jem.110.3.389. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Berry L. J. Bacterial toxins. CRC Crit Rev Toxicol. 1977 Nov;5(3):239–318. doi: 10.3109/10408447709082601. [DOI] [PubMed] [Google Scholar]
  5. Berry L. J., Smythe D. S., Colwell L. S. Inhibition of inducible liver enzymes by endotoxin and actinomycin D. J Bacteriol. 1966 Jul;92(1):107–115. doi: 10.1128/jb.92.1.107-115.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Berry L. J., Smythe D. S., Colwell L. S., Schoengold R. J., Actor P. Comparison of the effects of a synthetic polyribonucleotide with the effects of endotoxin on selected host responses. Infect Immun. 1971 Mar;3(3):444–448. doi: 10.1128/iai.3.3.444-448.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Braun W. Relationships between the effects of poly I. poly C and endotoxin. Nature. 1969 Dec 6;224(5223):1024–1025. doi: 10.1038/2241024a0. [DOI] [PubMed] [Google Scholar]
  8. Carswell E. A., Old L. J., Kassel R. L., Green S., Fiore N., Williamson B. An endotoxin-induced serum factor that causes necrosis of tumors. Proc Natl Acad Sci U S A. 1975 Sep;72(9):3666–3670. doi: 10.1073/pnas.72.9.3666. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. DeClercq E., DeSomer P. Local Shwartzman phenomenon in athymic nude mice. Proc Soc Exp Biol Med. 1980 May;164(1):75–81. [PubMed] [Google Scholar]
  10. Filkins J. P., Buchanan B. J. In vivo vs in vitro effects of endotoxin on glycogenolysis, gluconeogenesis, and glucose utlization. Proc Soc Exp Biol Med. 1977 Jun;155(2):216–218. doi: 10.3181/00379727-155-39776. [DOI] [PubMed] [Google Scholar]
  11. Gold J. Proposed treatment of cancer by inhibition of gluconeogenesis. Oncology. 1968;22(2):185–207. doi: 10.1159/000224450. [DOI] [PubMed] [Google Scholar]
  12. Goodrum K. J., Berry L. J. The use of Reuber hepatoma cells for the study of a lipopolysaccharide-induced macrophage factor: glucocorticoid-antagonizing factor. Lab Invest. 1979 Aug;41(2):174–181. [PubMed] [Google Scholar]
  13. Green S., Dobrjansky A., Carswell E. A., Kassel R. L., Old L. J., Fiore N., Schwartz M. K. Partial purification of a serum factor that causes necrosis of tumors. Proc Natl Acad Sci U S A. 1976 Feb;73(2):381–385. doi: 10.1073/pnas.73.2.381. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Gresser I., Maury C., Bandu M. T., Tovey M., Maunoury M. T. Role of endogenous interferon in the anti-tumor effect of poly I-C and statolon as demonstrated by the use of anti-mouse interferon serum. Int J Cancer. 1978 Jan 15;21(1):72–77. doi: 10.1002/ijc.2910210113. [DOI] [PubMed] [Google Scholar]
  15. Gresser I., Tovey M. G., Bandu M. E., Maury C., Brouty-Boyé D. Role of interferon in the pathogenesis of virus diseases in mice as demonstrated by the use of anti-interferon serum. I. Rapid evolution of encephalomyocarditis virus infection. J Exp Med. 1976 Nov 2;144(5):1305–1315. doi: 10.1084/jem.144.5.1305. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Gresser I., Tovey M. G., Maury C., Chouroulinkov I. Lethality of interferon preparations for newborn mice. Nature. 1975 Nov 6;258(5530):76–78. doi: 10.1038/258076a0. [DOI] [PubMed] [Google Scholar]
  17. Hallum J. V., Youngner J. S., Stinebring W. R. Interferon activity associated with high molecular weight proteins in the circulation of mice injected with endotoxin or bacteria. Virology. 1965 Nov;27(3):429–431. doi: 10.1016/0042-6822(65)90124-8. [DOI] [PubMed] [Google Scholar]
  18. Homan E. R., Zendzian R. P., Schott L. D., Levy H. B., Adamson R. H. Studies on poly I:C toxicity in experimental animals. Toxicol Appl Pharmacol. 1972 Dec;23(4):579–588. doi: 10.1016/0041-008x(72)90098-1. [DOI] [PubMed] [Google Scholar]
  19. LaNoue K. F., Mason A. D., Jr, Daniels J. P. The impairment of glucogenesis by gram negative infection. Metabolism. 1968 Jul;17(7):606–611. doi: 10.1016/0026-0495(68)90019-x. [DOI] [PubMed] [Google Scholar]
  20. Leonard B. J., Eccleston E., Jones D. Toxicity of interferon inducers of the double stranded RNA type. Nature. 1969 Dec 6;224(5223):1023–1024. doi: 10.1038/2241023a0. [DOI] [PubMed] [Google Scholar]
  21. Lindsay H. L., Trown P. W., Brandt J., Forbes M. Pyrogenicity of poly I. poly C in rabbits. Nature. 1969 Aug 16;223(5207):717–718. doi: 10.1038/223717a0. [DOI] [PubMed] [Google Scholar]
  22. Moore R. N., Berry L. J., Garry R. F., Waite M. R. Effect of Sindbis virus infection on hydrocortisone-induced hepatic enzymes in mice. Proc Soc Exp Biol Med. 1978 Jan;157(1):125–128. doi: 10.3181/00379727-157-40005. [DOI] [PubMed] [Google Scholar]
  23. Moore R. N., Berry L. J. Inhibited hormonal induction of hepatic phosphoenolpyruvate carboxykinase in poly I: treated mice, an endotoxin-like glucocorticoid antagonism. Experientia. 1976 Dec 15;32(12):1566–1568. doi: 10.1007/BF01924457. [DOI] [PubMed] [Google Scholar]
  24. Moore R. N., Goodrum K. J., Berry L. J. Mediation of an endotoxic effect by macrophages. J Reticuloendothel Soc. 1976 Mar;19(3):187–197. [PubMed] [Google Scholar]
  25. Moore R. N., Goodrum K. J., Couch R. E., Jr, Berry L. J. Elicitation of endotoxemic effects in C3H/HeJ mice with glucocorticoid antagonizing factor and partial characterization of the factor. Infect Immun. 1978 Jan;19(1):79–86. doi: 10.1128/iai.19.1.79-86.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Ray P. D., Foster D. O., Lardy H. A. Paths of carbon in gluconeogenesis and lipogenesis. IV. Inhibition by L-tryptophan of hepatic gluconeogenesis at the level of phosphoenolpyruvate formation. J Biol Chem. 1966 Sep 10;241(17):3904–3908. [PubMed] [Google Scholar]
  27. Renton K. W., Keyler D. E., Mannering G. J. Suppression of the inductive effects of phenobarbital and 3-methylcholanthrene on ascorbic acid synthesis and hepatic cytochrome P-450-linked monooxygenase systems by the interferon inducers, poly rI.rC and tilorone. Biochem Biophys Res Commun. 1979 Jun 13;88(3):1017–1023. doi: 10.1016/0006-291x(79)91510-9. [DOI] [PubMed] [Google Scholar]
  28. Renton K. W., Mannering G. J. Depression of hepatic cytochrome P-450-dependent monooxygenase systems with administered interferon inducing agents. Biochem Biophys Res Commun. 1976 Nov 22;73(2):343–348. doi: 10.1016/0006-291x(76)90713-0. [DOI] [PubMed] [Google Scholar]
  29. Rippe D. F., Berry L. J. Study of inhibition of induction of phosphoenolpyruvate carboxykinase by endotoxin with radial immunodiffusion. Infect Immun. 1972 Nov;6(5):766–772. doi: 10.1128/iai.6.5.766-772.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Rivière Y., Gresser I., Guillon J. C., Tovey M. G. Inhibition by anti-interferon serum of lymphocytic choriomeningitis virus disease in suckling mice. Proc Natl Acad Sci U S A. 1977 May;74(5):2135–2139. doi: 10.1073/pnas.74.5.2135. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. STINEBRING W. R., YOUNGNER J. S. PATTERNS OF INTERFERON APPEARANCE IN MICE INFECTED WITH BACTERIA OR BACTERIAL ENDOTOXIN. Nature. 1964 Nov 14;204:712–712. doi: 10.1038/204712a0. [DOI] [PubMed] [Google Scholar]
  32. Senterfitt V. C., Shands J. W., Jr Endotoxin induced metabolic alterations in BCG infected (hyperreactive) mice. Proc Soc Exp Biol Med. 1978 Oct;159(1):69–74. doi: 10.3181/00379727-159-40286. [DOI] [PubMed] [Google Scholar]
  33. Shands J. W., Jr, Miller V., Martin H., Senterfitt V. Hypoglycemic activity of endotoxin. II. Mechanism of the phenomenon in BCG-infected mice. J Bacteriol. 1969 May;98(2):494–501. doi: 10.1128/jb.98.2.494-501.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Shands J. W., Jr, Miller V., Martin H. The hypoglycemic activity of endotoxin. I. Occurrence in animals hyperreactive to endotoxin. Proc Soc Exp Biol Med. 1969 Feb;130(2):413–417. doi: 10.3181/00379727-130-33568. [DOI] [PubMed] [Google Scholar]
  35. Shands J. W., Jr, Senterfitt V. C. Endotoxin-induced hepatic damage in BCG-infected mice. Am J Pathol. 1972 Apr;67(1):23–40. [PMC free article] [PubMed] [Google Scholar]
  36. Shands J. W., Jr, Senterfitt V., Miller V. Endotoxin-induced insulin sensitivity in BCG infected mice. Proc Soc Exp Biol Med. 1971 Mar;136(3):983–986. doi: 10.3181/00379727-136-35411. [DOI] [PubMed] [Google Scholar]
  37. Tovey M. G., Begon-Lours J., Gresser I. A method for the large scale production of potent interferon preparations. Proc Soc Exp Biol Med. 1974 Jul;146(3):809–815. doi: 10.3181/00379727-146-38196. [DOI] [PubMed] [Google Scholar]
  38. Youngner J. S., Stinebring W. R. Interferon appearance stimulated by endotoxin, bacteria, or viruses in mice pre-treated with Escherichia coli endotoxin or infected with Mycobacterium tuberculosis. Nature. 1965 Oct 30;208(5009):456–458. doi: 10.1038/208456a0. [DOI] [PubMed] [Google Scholar]

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