Skip to main content
Infection and Immunity logoLink to Infection and Immunity
. 1981 Aug;33(2):519–522. doi: 10.1128/iai.33.2.519-522.1981

Regulation of the immune response to bacterial lipopolysaccharide by adherent cells.

M O Citron, J G Michael
PMCID: PMC350730  PMID: 7024131

Abstract

Immune response to bacterial lipopolysaccharide is usually short lived, but it often reappears without additional stimulus in a cyclic fashion. Activated adherent cells, presumably macrophages, were found to have a role in the reduction of the immune response to Escherichia coli O127 lipopolysaccharide. The suppressive activity of the adherent cells was abrogated before renewal of the responsiveness.

Full text

PDF
519

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allison A. C., Harington J. S., Birbeck M. An examination of the cytotoxic effects of silica on macrophages. J Exp Med. 1966 Aug 1;124(2):141–154. doi: 10.1084/jem.124.2.141. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Allison A. C. Mechanisms by which activated macrophages inhibit lymphocyte responses. Immunol Rev. 1978;40:3–27. doi: 10.1111/j.1600-065x.1978.tb00399.x. [DOI] [PubMed] [Google Scholar]
  3. Becker L. J., Rudback J. A. Altered antibody responses in mice treated with toxins for macrophages. J Reticuloendothel Soc. 1979 Apr;25(4):443–454. [PubMed] [Google Scholar]
  4. Britton S., Möller G. Regulation of antibody synthesis against Escherichia coli endotoxin. I. Suppressive effect of endogenously produced and passively transferred antibodies. J Immunol. 1968 Jun;100(6):1326–1334. [PubMed] [Google Scholar]
  5. Britton S., Wepsic T., Möller G. Persistence of immunogenicity of two complex antigens retained in vivo. Immunology. 1968 Apr;14(4):491–501. [PMC free article] [PubMed] [Google Scholar]
  6. Danneman P. J., Michael J. G. Adjuvant and immunogenic properties of bacterial lipopolysaccharide in IgE and IgG antibody formation in mice. Cell Immunol. 1976 Mar 1;22(1):128–139. doi: 10.1016/0008-8749(76)90014-9. [DOI] [PubMed] [Google Scholar]
  7. Kirchner H., Chused T. M., Herberman R. B., Holden H. T., Lavrin D. H. Evidence of suppressor cell activity in spleens of mice bearing primary tumors induced by Moloney sarcoma virus. J Exp Med. 1974 Jun 1;139(6):1473–1487. doi: 10.1084/jem.139.6.1473. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Kirchner H., Muchmore A. V., Chused T. M., Holden H. T., Herberman R. B. Inhibition of proliferation of lymphoma cells and T lymphocytes by suppressor cells from spleens of tumor-bearing mice. J Immunol. 1975 Jan;114(1 Pt 1):206–210. [PubMed] [Google Scholar]
  9. Lemke H., Coutinho A., Opitz H. G., Gronowicz E. Macrophages suppress direct B-cell activation by lipopolysaccharide. Scand J Immunol. 1975;4(7):707–720. doi: 10.1111/j.1365-3083.1975.tb02679.x. [DOI] [PubMed] [Google Scholar]
  10. Poe W. J., Michael J. G. Separation of the mitogenic and antigenic responses to bacterial lipopolysaccharide. Immunology. 1976 Feb;30(2):241–248. [PMC free article] [PubMed] [Google Scholar]
  11. Poe W. J., Michael J. G. The lack of cellular cooperation in the immune response to E. coli 0127. J Immunol. 1974 Sep;113(3):1033–1038. [PubMed] [Google Scholar]
  12. Romball C. G., Weigle W. O. Modulation of regulatory mechanisms operative in the cyclical production of antibody. J Exp Med. 1976 Mar 1;143(3):497–510. doi: 10.1084/jem.143.3.497. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Veit B. C., Feldman J. D. Altered lymphocyte functions in rats bearing syngeneic Moloney sarcoma tumors. II. Suppressor cells. J Immunol. 1976 Aug;117(2):655–660. [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES